Failure of bromocriptine to modify the response to metyrapone in normal subjects

Salvatore Maria Corsello, Giovina De Rosa, A Gulino, E Menini, E. Pasargiklian

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

In order to study the role played by the dopaminergic system on the secretion of ACTH, we evaluated the influence of bromocriptine on the response to metyrapone. Levels of serum cortisol and 11-deoxycortisol and of urinary 17-OH-corticosteroids and 17-ketosteroids were measured both before and after stimulation with metyrapone in ten normal adults. This was followed by a week of administration with bromocriptine (5 mg/die) after which the above measurements were repeated. The results obtained did not differ significantly. Thus it may concluded that, under these conditions and at this dose, bromocriptine does not modify the response to metyrapone.
Lingua originaleEnglish
pagine (da-a)153-157
Numero di pagine5
RivistaAnnales d'Endocrinologie
Volume42
Stato di pubblicazionePubblicato - 1981

Keywords

  • 17-Hydroxycorticosteroids
  • 17-Ketosteroids
  • Adolescent
  • Adult
  • Bromocriptine
  • Cortodoxone
  • Dopamine
  • Humans
  • Hydrocortisone
  • Male
  • Metyrapone
  • Middle Aged

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