Facts and artifacts in proteomics of body fluids. What proteomics of saliva is telling us?

Irene Messana, Rosanna Inzitari, Chiara Fanali, Tiziana Cabras, Massimo Castagnola

Risultato della ricerca: Contributo in rivistaArticolo in rivista

109 Citazioni (Scopus)


This review briefly depicts several salient points of the current status of knowledge on salivary peptidoma. It outlines the intrinsic difficulties in its characterization connected to different factors of variability, such as: i) the high genetic polymorphisms, complicated by individual insertions/deletions and alternative splicing; ii) complex post-translational maturations comprehending different proteolytic cleavages, glycosylation, phosphorylation and sulfation processes; iii) physiological variations and different contributions to the whole. Moreover, several technological and analytical problems and pitfalls that had to be surmounted during our studies focussed on the extensive qualitative and quantitative characterization of salivary peptidoma and mainly based on LC-MS analyses of intact naturally occurring peptides are here described. The hope is that the information provided might be helpful to other groups engaged on the analysis of saliva or other body fluids for clinical applications.
Lingua originaleEnglish
pagine (da-a)1948-1963
Numero di pagine16
RivistaJournal of Separation Science
Stato di pubblicazionePubblicato - 2008




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