Factors predicting survival in ALS: a multicenter Italian study

Andrea Calvo, Cristina Moglia, Christian Lunetta, Kalliopi Marinou, Nicola Ticozzi, Gianluca Drago Ferrante, Carlo Scialo, Gianni Sorarù, Francesca Trojsi, Amelia Conte, Yuri M. Falzone, Rosanna Tortelli, Massimo Russo, Adriano Chiò, Valeria Ada Sansone, Gabriele Mora, Vincenzo Silani, Paolo Volanti, Claudia Caponnetto, Giorgia QuerinMaria Rosaria Monsurrò, Mario Sabatelli, Nilo Riva, Giancarlo Logroscino, Giandomenico Logroscino, Sonia Messina, Nicola Fini, Jessica Mandrioli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

63 Citazioni (Scopus)


The aim of this multicenter, retrospective study is to investigate the role of clinical characteristics and therapeutic intervention on ALS prognosis. The study included patients diagnosed from January 1, 2009 to December 31, 2013 in 13 Italian referral centers for ALS located in 10 Italian regions. Caring neurologists collected a detailed phenotypic profile and follow-up data until death into an electronic database. One center collected also data from a population-based registry for ALS. 2648 incident cases were collected. The median survival time from onset to death/tracheostomy was 44 months (SE 1.18, CI 42–46). According to univariate analysis, factors related to survival from onset to death/tracheostomy were: age at onset, diagnostic delay, site of onset, phenotype, degree of certainty at diagnosis according to revised El Escorial criteria (R-EEC), presence/absence of dementia, BMI at diagnosis, patients’ provenance. In the multivariate analysis, age at onset, diagnostic delay, phenotypes but not site of onset, presence/absence of dementia, BMI, riluzole use, R-EEC criteria were independent prognostic factors of survival in ALS. We compared patients from an ALS Registry with patients from tertiary centers; the latter ones were younger, less frequently bulbar, but more frequently familial and definite at diagnosis. Our large, multicenter study demonstrated the role of some clinical and demographic factors on ALS survival, and showed some interesting differences between referral centers’ patients and the general ALS population. These results can be helpful for clinical practice, in clinical trial design and to validate new tools to predict disease progression.
Lingua originaleEnglish
pagine (da-a)54-63
Numero di pagine10
RivistaJournal of Neurology
Stato di pubblicazionePubblicato - 2017


  • ALS
  • Age of Onset
  • Aged
  • Amyotrophic Lateral Sclerosis
  • Body Mass Index
  • Delayed Diagnosis
  • Female
  • Follow-Up Studies
  • Humans
  • Italy
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Phenotype
  • Population-based registries
  • Prognosis
  • Prognostic factors
  • Referral centers
  • Retrospective Studies
  • Survival
  • Tertiary Care Centers


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