TY - JOUR
T1 - Factors predicting ischemic-type biliary lesions (ITBLs) after liver transplantation
AU - Avolio, Alfonso Wolfango
AU - Sganga, Gabriele
AU - Agnes, Salvatore
AU - Frongillo, Francesco
AU - Grossi, Ugo
AU - Nure, Erida
AU - Pepe, Gilda
AU - Bianco, Giuseppe
AU - Lirosi, Maria Carmen
AU - 33183,
AU - FACOLTA', DI MEDICINA E CHIRURGIA "A.GEMELLI"
AU - traslazionale, ROMA - Dipartimento di Medicina e chirurgia
PY - 2012
Y1 - 2012
N2 - Among biliary complications, ischemic-type biliary lesions (ITBLs) remain a major cause of morbidity in liver transplant recipients, significantly affecting the chance of survival of both patients and grafts. We retrospectively reviewed 10 years of prospectively collected donor and recipient data from April 2001 to April 2011. We evaluated the incidence of ITBL occurrence, exploring the possible predisposing factors, including donor and recipient data. Two hundred fifty-one grafts were harvested: 222 of them were transplanted at our institution, the remaining 29 (11.6%) discarded by our donor team as showing >40% macrovesicular steatosis. Mild-moderate (20%-40%) macrovesicular steatosis (P < .001) and cold ischemia time (P = .048) significantly increased the risk of ITBL, also as an independent risk factor after multivariate analysis.
AB - Among biliary complications, ischemic-type biliary lesions (ITBLs) remain a major cause of morbidity in liver transplant recipients, significantly affecting the chance of survival of both patients and grafts. We retrospectively reviewed 10 years of prospectively collected donor and recipient data from April 2001 to April 2011. We evaluated the incidence of ITBL occurrence, exploring the possible predisposing factors, including donor and recipient data. Two hundred fifty-one grafts were harvested: 222 of them were transplanted at our institution, the remaining 29 (11.6%) discarded by our donor team as showing >40% macrovesicular steatosis. Mild-moderate (20%-40%) macrovesicular steatosis (P < .001) and cold ischemia time (P = .048) significantly increased the risk of ITBL, also as an independent risk factor after multivariate analysis.
KW - BILIARY COMPLICATIONS
KW - BILIARY STENOSIS
KW - CHOLANGITIS
KW - ISCHEMIA
KW - LIVER TRANSPLANTATION
KW - NON STANDARD DONOR
KW - BILIARY COMPLICATIONS
KW - BILIARY STENOSIS
KW - CHOLANGITIS
KW - ISCHEMIA
KW - LIVER TRANSPLANTATION
KW - NON STANDARD DONOR
UR - http://hdl.handle.net/10807/37187
UR - http://www.transplantation-proceedings.org
U2 - 10.1016/j.transproceed.2012.06.008
DO - 10.1016/j.transproceed.2012.06.008
M3 - Article
VL - 44
SP - 2002
EP - 2004
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
ER -