Factors associated with mortality in bacteremic patients with haematologic malignancies

Mario Tumbarello, Teresa Spanu, Giovanni Fadda, Roberto Cauda, Livio Pagano, Morena Caira, Enrico Maria Trecarichi, Luca Laurenti, Eva Agostina Montuori, Luana Fianchi, Giuseppe Leone

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

70 Citazioni (Scopus)

Abstract

We conducted a retrospective cohort study to identify risk factors for mortality in a large cohort of hematologic patients with bacteremia. From 2000 through 2005, bacteremia was diagnosed in 217 patients with hematologic malignancies. The infections were caused only by Gram-positive organisms in 57.1% (124/217) cases and only by Gram-negative bacteria in 37.8% (82/217); the remaining 5.1% (11/217) were polymicrobial. The overall 30-day mortality rate was 20.3% (44/217). In multivariate analysis, significant predictors of mortality were prolonged neutropenia (P < 0.001), acute renal failure (P = 0.002), nosocomial bacteremia (P = 0.009), age >55 years (P = 0.007), and monomicrobial bacteremia due to antibiotic-resistant Gram-negative bacteria (P = 0.009). Reducing fatal outcomes associated with bacteremia in patients with hematologic malignancies is a challenge, and the emergence of resistance to the antimicrobials widely used in this setting is of great concern. Future infection trends must be carefully monitored and treatment guidelines adjusted accordingly.
Lingua originaleEnglish
pagine (da-a)320-326
Numero di pagine7
RivistaDiagnostic Microbiology and Infectious Disease
Volume64
Stato di pubblicazionePubblicato - 2009

Keywords

  • bacteremia
  • hematological malignancies
  • mortality

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