TY - JOUR
T1 - Extradural Motor Cortex Stimulation might improve episodic and working memory in patients with Parkinson’s disease
AU - Piano, Carla
AU - Ciavarro, Marco
AU - Bove, Francesco
AU - Di Giuda, Daniela
AU - Cocciolillo, Fabrizio
AU - Bentivoglio, Anna Rita
AU - Cioni, Beatrice
AU - Tufo, Tommaso
AU - Calabresi, Paolo
AU - Daniele, Antonio
PY - 2020
Y1 - 2020
N2 - Electric Extradural Motor Cortex Stimulation (EMCS) is a neurosurgical procedure suggested for treatment of patients with advanced Parkinson’s disease (PD). We report two PD patients treated by EMCS, who experienced worsening of motor symptoms and cognition 5 years after surgery, when EMCS batteries became discharged. One month after EMCS restoration, they experienced a subjective improvement of motor symptoms and cognition. Neuropsychological assessments were carried out before replacement of batteries (off-EMCS condition) and 6 months afterward (on-EMCS condition). As compared to off-EMCS condition, in on-EMCS condition both patients showed an improvement on tasks of verbal episodic memory and backward spatial short-term/working memory task, and a decline on tasks of selective visual attention and forward spatial short-term memory. These findings suggest that in PD patients EMCS may induce slight beneficial effects on motor symptoms and cognitive processes involved in verbal episodic memory and in active manipulation of information stored in working memory.
AB - Electric Extradural Motor Cortex Stimulation (EMCS) is a neurosurgical procedure suggested for treatment of patients with advanced Parkinson’s disease (PD). We report two PD patients treated by EMCS, who experienced worsening of motor symptoms and cognition 5 years after surgery, when EMCS batteries became discharged. One month after EMCS restoration, they experienced a subjective improvement of motor symptoms and cognition. Neuropsychological assessments were carried out before replacement of batteries (off-EMCS condition) and 6 months afterward (on-EMCS condition). As compared to off-EMCS condition, in on-EMCS condition both patients showed an improvement on tasks of verbal episodic memory and backward spatial short-term/working memory task, and a decline on tasks of selective visual attention and forward spatial short-term memory. These findings suggest that in PD patients EMCS may induce slight beneficial effects on motor symptoms and cognitive processes involved in verbal episodic memory and in active manipulation of information stored in working memory.
KW - Extradural Motor Cortex
KW - Parkinson's disease
KW - Extradural Motor Cortex
KW - Parkinson's disease
UR - http://hdl.handle.net/10807/165897
U2 - 10.1038/s41531-020-00129-8
DO - 10.1038/s41531-020-00129-8
M3 - Article
SN - 2373-8057
VL - 6
SP - 1
EP - 6
JO - npj Parkinson's Disease
JF - npj Parkinson's Disease
ER -