Extradural Motor Cortex Stimulation in Parkinson's Disease: Long-Term Clinical Outcome.

Carla Piano, Francesco Bove*, Delia Mulas, Enrico Di Stasio, Alfonso Fasano, Anna Rita Bentivoglio, Antonio Daniele, Beatrice Cioni, Paolo Calabresi, Tommaso Tufo

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review


Previous investigations have reported on the motor benefits and safety of chronic extradural motor cortex stimulation (EMCS) for patients with Parkinson’s disease (PD), but studies addressing the long-term clinical outcome are still lacking. In this study, nine consecutive PD patients who underwent EMCS were prospectively recruited, with a mean follow-up time of 5.1 ± 2.5 years. As compared to the preoperatory baseline, the Unified Parkinson’s Disease Rating Scale (UPDRS)-III in the off-medication condition significantly decreased by 13.8% at 12 months, 16.1% at 18 months, 18.4% at 24 months, 21% at 36 months, 15.6% at 60 months, and 8.6% at 72 months. The UPDRS-IV decreased by 30.8% at 12 months, 22.1% at 24 months, 25% at 60 months, and 36.5% at 72 months. Dopaminergic therapy showed a progressive reduction, significant at 60 months (11.8%). Quality of life improved by 18.0% at 12 months, and 22.4% at 60 months. No surgical complication, cognitive or behavioral change occurred. The only adverse event reported was an infection of the implantable pulse generator pocket. Even in the long-term follow-up, EMCS was shown to be a safe and effective treatment option in PD patients, resulting in improvements in motor symptoms and quality of life, and reductions in motor complications and dopaminergic therapy.
Lingua originaleEnglish
pagine (da-a)1-12
Numero di pagine12
RivistaBrain Sciences
Stato di pubblicazionePubblicato - 2021


  • Parkinson's Disease


Entra nei temi di ricerca di 'Extradural Motor Cortex Stimulation in Parkinson's Disease: Long-Term Clinical Outcome.'. Insieme formano una fingerprint unica.

Cita questo