Extracranial Venous Drainage Pattern in Multiple Sclerosis and Healthy Controls: Application of the 2011 Diagnostic Criteria for Chronic Cerebrospinal Venous Insufficiency

Paolo Calabresi, Gabriela Cardaioli, Massimiliano Di Filippo, Alessia Bianchi, Paolo Eusebi, Maria Di Gregorio, Lorenzo Gaetani, Antongiulio Gallina, Paola Sarchielli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

5 Citazioni (Scopus)

Abstract

The etiology of multiple sclerosis (MS) is still largely unknown and it has been proposed that an impaired venous drainage from the central nervous system, defined as chronic cerebrospinal venous insufficiency (CCSVI), may play a role in this. We investigated the prevalence of extracranial venous drainage pattern alterations in a cohort of MS patients based on the 2011 revised diagnostic criteria for CCSVI. Thirty-nine MS patients and 18 healthy subjects underwent blinded extra-cranial venous echo-color Doppler sonography to reveal the presence of CCSVI. There was no statistically significant difference between MS patients and healthy controls regarding CCSVI prevalence (p value = 0.53). The results challenge the hypothesis that CCSVI plays a primary role in the pathogenesis of MS.
Lingua originaleEnglish
pagine (da-a)62-68
Numero di pagine7
RivistaEuropean Neurology
Volume76
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Adult
  • Case-Control Studies
  • Cerebral venous outflow
  • Chronic cerebrospinal venous insufficiency
  • Echo-color Doppler sonography
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis
  • Multiple sclerosis
  • Prevalence
  • Ultrasonography, Doppler, Transcranial
  • Venous Insufficiency

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