TY - JOUR
T1 - Extracorporeal photochemotherapy for paediatric patients with graft-versus-host disease after haematopoietic stem cell transplantation
AU - Messina, Chiara
AU - Locatelli, Franco
AU - Lanino, Edoardo
AU - Uderzo, Cornelio
AU - Zacchello, Graziella
AU - Cesaro, Simone
AU - Pillon, Marta
AU - Perotti, Cesare
AU - Del Fante, Claudia
AU - Faraci, Maura
AU - Rivabella, Lucia
AU - Calore, Elisabetta
AU - De Stefano, Pietro
AU - Zecca, Marco
AU - Giorgiani, Giovanna
AU - Brugiolo, Alessandra
AU - Balduzzi, Adriana
AU - Dini, Giorgio
AU - Zanesco, Luigi
AU - Dall'Amico, Roberto
PY - 2003
Y1 - 2003
N2 - This study aimed to ascertain whether extracorporeal photochemotherapy (ECP) is an effective treatment for paediatric patients with refractory graft-versus-host disease (GVHD). From January 1992 to December 2000, 77 children (median age 8.6 years) with either acute (n = 33) or chronic (n = 44) GVHD, resistant to conventional immunosuppressive therapy, were treated with ECP in four Italian paediatric hospitals. After ECP, acute GVHD involving skin, liver and gut responded completely in 76%, 60% and 75% of patients respectively. The 5-year overall survival was 69% for responding patients vs 12% for non-responders (P = 0.001). Among the 44 children with chronic GVHD, 15 (44%) showed a complete response and 10 (29%) a significant improvement after ECP. The 5-year overall survival was 96% for responders vs 58% for non-responders (P = 0.04). Our results suggest that ECP is an effective treatment that may be useful in paediatric patients with either acute or chronic GVHD who have failed to respond to standard immunosuppressive therapy.
AB - This study aimed to ascertain whether extracorporeal photochemotherapy (ECP) is an effective treatment for paediatric patients with refractory graft-versus-host disease (GVHD). From January 1992 to December 2000, 77 children (median age 8.6 years) with either acute (n = 33) or chronic (n = 44) GVHD, resistant to conventional immunosuppressive therapy, were treated with ECP in four Italian paediatric hospitals. After ECP, acute GVHD involving skin, liver and gut responded completely in 76%, 60% and 75% of patients respectively. The 5-year overall survival was 69% for responding patients vs 12% for non-responders (P = 0.001). Among the 44 children with chronic GVHD, 15 (44%) showed a complete response and 10 (29%) a significant improvement after ECP. The 5-year overall survival was 96% for responders vs 58% for non-responders (P = 0.04). Our results suggest that ECP is an effective treatment that may be useful in paediatric patients with either acute or chronic GVHD who have failed to respond to standard immunosuppressive therapy.
KW - extracorporeal photochemotherapy (ECP)
KW - haematopoietic stem cell transplantation
KW - graft-versus-host disease (GVHD)
KW - extracorporeal photochemotherapy (ECP)
KW - haematopoietic stem cell transplantation
KW - graft-versus-host disease (GVHD)
UR - http://hdl.handle.net/10807/262058
U2 - 10.1046/j.1365-2141.2003.04401.x
DO - 10.1046/j.1365-2141.2003.04401.x
M3 - Article
SN - 0007-1048
VL - 122
SP - 118
EP - 127
JO - British Journal of Haematology
JF - British Journal of Haematology
ER -