TY - JOUR
T1 - External Validation of a Prognostic Score for Survival in Lung Carcinoids
AU - Chiappetta, M.
AU - Tabacco, D.
AU - Sassorossi, C.
AU - Sperduti, I.
AU - Cusumano, G.
AU - Terminella, A.
AU - Fournel, L.
AU - Alifano, M.
AU - Guerrera, F.
AU - Filosso, P. L.
AU - Nicosia, S.
AU - Gallina, F.
AU - Facciolo, F.
AU - Margaritora, Stefano
AU - Lococo, Filippo
PY - 2022
Y1 - 2022
N2 - Background: A prognostic score including T-dimension, age, histology and lymph node ratio was previously proposed in absence of an external validation dataset. The aim of the current study was to validate the proposed prognostic score using an independent dataset. Methods: Data of patients with lung carcinoids, who underwent surgical resection and lymphadenectomy in five institutions from 1 January 2005 to 31 December 2019, were retrospectively analyzed. Two risk groups were created based on the following data: age, histology, node ratio and pT for disease-free survival (DFS); age, sex, node ratio and pT for overall survival (OS). The previously proposed score was validated, identifying two groups of patients: a high risk (HRG) and low risk (LRG) group. Results: The final analysis was conducted on 283 patients. Regarding DFS, 230 (81.3%) patients were assigned to the LRG and 53 (18.7%) to the HRG. Considering OS, 268 (94.7%) were allocated in the LRG and 15 (5.3%) in the HRG. The 5-year DFS was 92.7% in the LRG vs. 67% in the HRG (p < 0.001) while the 5-year OS was 93.6% in the LRG vs. 86.2% in the HRG (p = 0.29) with clear curve separation. Conclusion: Our analysis confirmed the validity of the composite score for DFS in lung carcinoids. Regarding OS, statistical significance was not reached because of a low number of deaths and patients in the HRG.
AB - Background: A prognostic score including T-dimension, age, histology and lymph node ratio was previously proposed in absence of an external validation dataset. The aim of the current study was to validate the proposed prognostic score using an independent dataset. Methods: Data of patients with lung carcinoids, who underwent surgical resection and lymphadenectomy in five institutions from 1 January 2005 to 31 December 2019, were retrospectively analyzed. Two risk groups were created based on the following data: age, histology, node ratio and pT for disease-free survival (DFS); age, sex, node ratio and pT for overall survival (OS). The previously proposed score was validated, identifying two groups of patients: a high risk (HRG) and low risk (LRG) group. Results: The final analysis was conducted on 283 patients. Regarding DFS, 230 (81.3%) patients were assigned to the LRG and 53 (18.7%) to the HRG. Considering OS, 268 (94.7%) were allocated in the LRG and 15 (5.3%) in the HRG. The 5-year DFS was 92.7% in the LRG vs. 67% in the HRG (p < 0.001) while the 5-year OS was 93.6% in the LRG vs. 86.2% in the HRG (p = 0.29) with clear curve separation. Conclusion: Our analysis confirmed the validity of the composite score for DFS in lung carcinoids. Regarding OS, statistical significance was not reached because of a low number of deaths and patients in the HRG.
KW - lung carcinoid
KW - lymph nodes
KW - lymphadenectomy
KW - upstaging
KW - lung carcinoid
KW - lymph nodes
KW - lymphadenectomy
KW - upstaging
UR - https://publicatt.unicatt.it/handle/10807/228446
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85133124200&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85133124200&origin=inward
U2 - 10.3390/cancers14112601
DO - 10.3390/cancers14112601
M3 - Article
SN - 2072-6694
VL - 14
SP - N/A-N/A
JO - Cancers
JF - Cancers
IS - 11
ER -