Expression of liquoral neuroprotection markers
in children with acute lymphoblastic leukemia

Antonio Chiaretti; Antonio Ruggiero; Paola Coccia; Alessia Antonelli; Filomena Pierri; Giovanni Barone; Giorgio Attina'; Laura Iuvone; Palma Maurizi; Riccardo Riccardi

doi:10.1016/j.leukres.2011.07.025

Expression of liquoral neuroprotection markers in children with acute lymphoblastic leukemia

Antonio Chiaretti, Antonio Ruggiero, Paola Coccia, Alessia Antonelli, Filomena Pierri, Giovanni Barone, Giorgio Attina', Laura Iuvone, Palma Maurizi, Riccardo Riccardi

Risultato della ricerca: Contributo in rivista › Articolo in rivista

1 Citazioni (Scopus)

Abstract

Brain damage related to intrathecal methotrexate in children with acute lymphoblastic leukemia (ALL) is still unclear. Neuroinflammatory mechanisms and intracerebral production of specific biomarkers, play a key role in determining neuroprotective mechanisms after brain injury. To determine whether the CSF concentrations of neuron-specific enolase (NSE), neurotrophic factors and doublecortin (DCX) are influenced by repeated intrathecal methotrexate administrations, we prospectively collected CSF samples from 10 children with ALL and 10 controls. Our results showed an increased expression of the liquoral markers. This up-regulation could be interpreted as a neuroprotective response of the brain against the neuronal damages induced by MTX.

Lingua originale	English
pagine (da-a)	1467-1471
Numero di pagine	5
Rivista	Leukemia Research
Volume	35
DOI	https://doi.org/10.1016/j.leukres.2011.07.025
Stato di pubblicazione	Pubblicato - 2011

Keywords

Acute lymphoblastic leukemia
Children

Accesso al documento

10.1016/j.leukres.2011.07.025

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title = "Expression of liquoral neuroprotection markers in children with acute lymphoblastic leukemia",

abstract = "Brain damage related to intrathecal methotrexate in children with acute lymphoblastic leukemia (ALL) is still unclear. Neuroinflammatory mechanisms and intracerebral production of specific biomarkers, play a key role in determining neuroprotective mechanisms after brain injury. To determine whether the CSF concentrations of neuron-specific enolase (NSE), neurotrophic factors and doublecortin (DCX) are influenced by repeated intrathecal methotrexate administrations, we prospectively collected CSF samples from 10 children with ALL and 10 controls. Our results showed an increased expression of the liquoral markers. This up-regulation could be interpreted as a neuroprotective response of the brain against the neuronal damages induced by MTX.",

keywords = "Acute lymphoblastic leukemia, Children, Acute lymphoblastic leukemia, Children",

author = "Antonio Chiaretti and Antonio Ruggiero and Paola Coccia and Alessia Antonelli and Filomena Pierri and Giovanni Barone and Giorgio Attina' and Laura Iuvone and Palma Maurizi and Riccardo Riccardi",

year = "2011",

doi = "10.1016/j.leukres.2011.07.025",

language = "English",

volume = "35",

pages = "1467--1471",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Oxford,United Kingdom: Elsevier Science Limited -Oxford : Pergamon, 1977-",

}

TY - JOUR

T1 - Expression of liquoral neuroprotection markers in children with acute lymphoblastic leukemia

AU - Chiaretti, Antonio

AU - Ruggiero, Antonio

AU - Coccia, Paola

AU - Antonelli, Alessia

AU - Pierri, Filomena

AU - Barone, Giovanni

AU - Attina', Giorgio

AU - Iuvone, Laura

AU - Maurizi, Palma

AU - Riccardi, Riccardo

PY - 2011

Y1 - 2011

N2 - Brain damage related to intrathecal methotrexate in children with acute lymphoblastic leukemia (ALL) is still unclear. Neuroinflammatory mechanisms and intracerebral production of specific biomarkers, play a key role in determining neuroprotective mechanisms after brain injury. To determine whether the CSF concentrations of neuron-specific enolase (NSE), neurotrophic factors and doublecortin (DCX) are influenced by repeated intrathecal methotrexate administrations, we prospectively collected CSF samples from 10 children with ALL and 10 controls. Our results showed an increased expression of the liquoral markers. This up-regulation could be interpreted as a neuroprotective response of the brain against the neuronal damages induced by MTX.

AB - Brain damage related to intrathecal methotrexate in children with acute lymphoblastic leukemia (ALL) is still unclear. Neuroinflammatory mechanisms and intracerebral production of specific biomarkers, play a key role in determining neuroprotective mechanisms after brain injury. To determine whether the CSF concentrations of neuron-specific enolase (NSE), neurotrophic factors and doublecortin (DCX) are influenced by repeated intrathecal methotrexate administrations, we prospectively collected CSF samples from 10 children with ALL and 10 controls. Our results showed an increased expression of the liquoral markers. This up-regulation could be interpreted as a neuroprotective response of the brain against the neuronal damages induced by MTX.

KW - Acute lymphoblastic leukemia

KW - Children

KW - Acute lymphoblastic leukemia

KW - Children

UR - http://hdl.handle.net/10807/6706

U2 - 10.1016/j.leukres.2011.07.025

DO - 10.1016/j.leukres.2011.07.025

M3 - Article

SN - 0145-2126

VL - 35

SP - 1467

EP - 1471

JO - Leukemia Research

JF - Leukemia Research