Abstract
The expression of the proto-oncogene c-myc was studied in tumorous skin lesions of (cutaneous) lymphoproliferative diseases (3 cases of pseudolymphoma, 8 cases of non-Hodgkin lymphoma and 1 case of lymph node involvement in mycosis fungoides) in a total of 12 patients. c-myc mRNA levels were quantified by Northern blot analysis followed by densitometric evaluation of the specific bands. Higher levels of c-myc mRNA expression were observed in lymphomas as compared with pseudolymphomas (p greater than 0.05). No significant differences in c-myc mRNA values were detected between B and T cell pseudolymphomas. Our results suggest that c-myc mRNA overexpression is associated with malignant lymphomas of the skin. We conclude that the measurement of c-myc mRNA levels may contribute to further characterize cutaneous lymphoproliferative diseases.
Lingua originale | English |
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pagine (da-a) | 1-6 |
Numero di pagine | 6 |
Rivista | Dermatologica |
Volume | 183 |
Stato di pubblicazione | Pubblicato - 1991 |
Keywords
- Blotting, Northern
- Humans
- Lymphoma
- Proto-Oncogene Proteins c-myc
- RNA, Messenger
- Skin Neoplasms