Abstract
In this study we used an immunocytochemical approach to study nestin expression in the rat hippocampus during trimethyltin-induced neurodegeneration at different time points (5, 10, 15, 21 and 50 days) after intoxication. Nestin is transiently expressed by a subpopulation of astroglial cells strictly associated with pyramidal neurons in those hippocampal areas severely affected by degeneration. This observation shows that cerebral tissue re-expresses this developmental protein during neurodegenerative diseases in early stages of astroglial activation.
| Lingua originale | English |
|---|---|
| pagine (da-a) | 103-106 |
| Numero di pagine | 4 |
| Rivista | Neuroscience Letters |
| Stato di pubblicazione | Pubblicato - 2004 |
Keywords
- Astrocytic
- hippocampus
- nestin
- neurodegeneration
- trimethyltin-induced