Expression of astrocytic nestin in the rat hippocampus during trimethyltin-induced neurodegeneration

Maria Concetta Geloso, Valentina Corvino, Amelia Toesca Di Castellazzo, Valentina Cavallo, Enrico Guadagni, Roberto Passalacqua, Fabrizio Michetti

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

45 Citazioni (Scopus)

Abstract

In this study we used an immunocytochemical approach to study nestin expression in the rat hippocampus during trimethyltin-induced neurodegeneration at different time points (5, 10, 15, 21 and 50 days) after intoxication. Nestin is transiently expressed by a subpopulation of astroglial cells strictly associated with pyramidal neurons in those hippocampal areas severely affected by degeneration. This observation shows that cerebral tissue re-expresses this developmental protein during neurodegenerative diseases in early stages of astroglial activation.
Lingua originaleEnglish
pagine (da-a)103-106
Numero di pagine4
RivistaNeuroscience Letters
Stato di pubblicazionePubblicato - 2004

Keywords

  • Astrocytic
  • hippocampus
  • nestin
  • neurodegeneration
  • trimethyltin-induced

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