Exposure to HIV-protease inhibitors selects for increased expression of P-glycoprotein (ABCB1) in Kaposi's sarcoma cells

Mothanje Barbara Patricia Lucia, Roberto Cauda, R Anu, M Handley, J Gillet, C Wu, Gm De Donatis, Mm Gottesman

Risultato della ricerca: Contributo in rivistaArticolo in rivista

12 Citazioni (Scopus)

Abstract

Given that HIV-protease inhibitors (HIV-PIs) are substrates/inhibitors of the multidrug transporter ABCB1, can induce ABCB1 expression, and are used in combination with doxorubicin for AIDS-Kaposi's Sarcoma (KS) treatment, the role that ABCB1 plays in mediating multidrug resistance (MDR) in a fully transformed KS cell line (SLK) was explored.
Lingua originaleEnglish
pagine (da-a)513-522
Numero di pagine10
RivistaBritish Journal of Cancer
Volume105
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Antibiotics, Antineoplastic
  • Blotting, Western
  • Cell Line, Tumor
  • Doxorubicin
  • Drug Resistance, Multiple
  • Drug Resistance, Neoplasm
  • Drug Synergism
  • Flow Cytometry
  • Fluorescent Antibody Technique
  • Gene Expression Regulation, Neoplastic
  • HIV Infections
  • HIV Protease Inhibitors
  • Humans
  • Indinavir
  • Lopinavir
  • Nelfinavir
  • Oligopeptides
  • P-Glycoprotein
  • Pyridines
  • Pyrimidinones
  • Reverse Transcriptase Polymerase Chain Reaction
  • Ritonavir
  • Sarcoma, Kaposi
  • Treatment Outcome

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