Exposure to HIV-protease inhibitors selects for increased expression of P-glycoprotein (ABCB1) in Kaposi's sarcoma cells

Mothanje Barbara Patricia Lucia; R Anu; M Handley; J Gillet; C Wu; Gm De Donatis; Roberto Cauda; Mm Gottesman

doi:10.1038/bjc.2011.275

Exposure to HIV-protease inhibitors selects for increased expression of P-glycoprotein (ABCB1) in Kaposi's sarcoma cells

Mothanje Barbara Patricia Lucia, R Anu, M Handley, J Gillet, C Wu, Gm De Donatis, Roberto Cauda, Mm Gottesman

Risultato della ricerca: Contributo in rivista › Articolo in rivista

12 Citazioni (Scopus)

Abstract

Given that HIV-protease inhibitors (HIV-PIs) are substrates/inhibitors of the multidrug transporter ABCB1, can induce ABCB1 expression, and are used in combination with doxorubicin for AIDS-Kaposi's Sarcoma (KS) treatment, the role that ABCB1 plays in mediating multidrug resistance (MDR) in a fully transformed KS cell line (SLK) was explored.

Lingua originale	English
pagine (da-a)	513-522
Numero di pagine	10
Rivista	British Journal of Cancer
Volume	105
DOI	https://doi.org/10.1038/bjc.2011.275
Stato di pubblicazione	Pubblicato - 2011

Keywords

Antibiotics, Antineoplastic
Blotting, Western
Cell Line, Tumor
Doxorubicin
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Drug Synergism
Flow Cytometry
Fluorescent Antibody Technique
Gene Expression Regulation, Neoplastic
HIV Infections
HIV Protease Inhibitors
Humans
Indinavir
Lopinavir
Nelfinavir
Oligopeptides
P-Glycoprotein
Pyridines
Pyrimidinones
Reverse Transcriptase Polymerase Chain Reaction
Ritonavir
Sarcoma, Kaposi
Treatment Outcome

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10.1038/bjc.2011.275

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title = "Exposure to HIV-protease inhibitors selects for increased expression of P-glycoprotein (ABCB1) in Kaposi's sarcoma cells",

abstract = "Given that HIV-protease inhibitors (HIV-PIs) are substrates/inhibitors of the multidrug transporter ABCB1, can induce ABCB1 expression, and are used in combination with doxorubicin for AIDS-Kaposi's Sarcoma (KS) treatment, the role that ABCB1 plays in mediating multidrug resistance (MDR) in a fully transformed KS cell line (SLK) was explored.",

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author = "Lucia, {Mothanje Barbara Patricia} and R Anu and M Handley and J Gillet and C Wu and {De Donatis}, Gm and Roberto Cauda and Mm Gottesman",

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doi = "10.1038/bjc.2011.275",

language = "English",

volume = "105",

pages = "513--522",

journal = "British Journal of Cancer",

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AU - Lucia, Mothanje Barbara Patricia

AU - Anu, R

AU - Handley, M

AU - Gillet, J

AU - Wu, C

AU - De Donatis, Gm

AU - Cauda, Roberto

AU - Gottesman, Mm

PY - 2011

Y1 - 2011

N2 - Given that HIV-protease inhibitors (HIV-PIs) are substrates/inhibitors of the multidrug transporter ABCB1, can induce ABCB1 expression, and are used in combination with doxorubicin for AIDS-Kaposi's Sarcoma (KS) treatment, the role that ABCB1 plays in mediating multidrug resistance (MDR) in a fully transformed KS cell line (SLK) was explored.

AB - Given that HIV-protease inhibitors (HIV-PIs) are substrates/inhibitors of the multidrug transporter ABCB1, can induce ABCB1 expression, and are used in combination with doxorubicin for AIDS-Kaposi's Sarcoma (KS) treatment, the role that ABCB1 plays in mediating multidrug resistance (MDR) in a fully transformed KS cell line (SLK) was explored.

KW - Antibiotics, Antineoplastic

KW - Blotting, Western

KW - Cell Line, Tumor

KW - Doxorubicin

KW - Drug Resistance, Multiple

KW - Drug Resistance, Neoplasm

KW - Drug Synergism

KW - Flow Cytometry

KW - Fluorescent Antibody Technique

KW - Gene Expression Regulation, Neoplastic

KW - HIV Infections

KW - HIV Protease Inhibitors

KW - Humans

KW - Indinavir

KW - Lopinavir

KW - Nelfinavir

KW - Oligopeptides

KW - P-Glycoprotein

KW - Pyridines

KW - Pyrimidinones

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Ritonavir

KW - Sarcoma, Kaposi

KW - Treatment Outcome

KW - Antibiotics, Antineoplastic

KW - Blotting, Western

KW - Cell Line, Tumor

KW - Doxorubicin

KW - Drug Resistance, Multiple

KW - Drug Resistance, Neoplasm

KW - Drug Synergism

KW - Flow Cytometry

KW - Fluorescent Antibody Technique

KW - Gene Expression Regulation, Neoplastic

KW - HIV Infections

KW - HIV Protease Inhibitors

KW - Humans

KW - Indinavir

KW - Lopinavir

KW - Nelfinavir

KW - Oligopeptides

KW - P-Glycoprotein

KW - Pyridines

KW - Pyrimidinones

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Ritonavir

KW - Sarcoma, Kaposi

KW - Treatment Outcome

UR - http://hdl.handle.net/10807/19959

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DO - 10.1038/bjc.2011.275

M3 - Article

SN - 1532-1827

VL - 105

SP - 513

EP - 522

JO - British Journal of Cancer

JF - British Journal of Cancer

ER -

Exposure to HIV-protease inhibitors selects for increased expression of P-glycoprotein (ABCB1) in Kaposi's sarcoma cells

Abstract

Keywords

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