Exploiting immunotherapy in Mycobacterium tuberculosis-infected mice: sphingosine 1-phosphate treatment results in a protective or detrimental effect depending on the stage of infection

Michela Sali, Giovanni Delogu, Giovanni Fadda, E Greco, S Rocca, V Colizzi, M. Fraziano

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

Sphingosine 1-phosphate (S1P) is a natural lysophospholipid able to enhance antimycobacterial innate immune response. In the present study, we address the possible therapeutic role of S1P administered during primary or acute infection in mice aerogenically infected with Mycobacterium tuberculosis (MTB). Results show that the administration of S1P during primary infection significantly reduces the presence of MTB-infected cells within pulmonary granulomas and mycobacterial burden in the lung and in the spleen. However, if S1P treatment was started during acute infection, a detrimental effect was observed in terms of pulmonary histopathology and mycobacterial burden in the lung and in the spleen. Taken together, these results show that S1P can exert a therapeutic effect as a treatment of primary infection only.
Lingua originaleEnglish
pagine (da-a)175-181
Numero di pagine7
RivistaInternational Journal of Immunopathology and Pharmacology
Volume22
Stato di pubblicazionePubblicato - 2009

Keywords

  • Animals
  • Female
  • Immunity, Innate
  • Immunotherapy
  • Lung
  • Lysophospholipids
  • Mice
  • Mice, Inbred BALB C
  • Sphingosine
  • Tuberculosis

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