Expiratory and phonation times as measures of disease severity in patients with Multiple Sclerosis. A case-control study

Sara Nordio, E. Bernitsas, F. Meneghello, K. Palmer, M. R. Stabile, L. Dipietro, Stadio A. Di

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

10 Citazioni (Scopus)

Abstract

Background: Speech disorders are common in patients with Multiple Sclerosis (MS). They can be assessed with several methods, which are however expensive, complex, and not easily accessible to physicians during routine clinic visits. This study aimed at measuring maximum phonation times, maximum expiratory times, and articulation abilities scores in patients with MS compared to healthy subjects and at investigating if any of these parameters could be used as a measure of MS progression. Methods: 50 MS patients and 50 gender- and age-matched healthy controls were enrolled in the study. Maximum expiratory times and maximum phonation times were collected from both groups. Articulation abilities were evaluated using the articulation subtest from the Fussi assessment (dysarthria scores). MS patients were evaluated with the Expanded Disability Status Scale (EDSS). Correlations between EDSS scores and maximum expiratory times, maximum phonation times, and dysarthria scores were calculated. Results: EDSS scores of MS patients ranged from 4.5 to 7.5. In MS patients, maximum expiratory times, maximum phonation times, and dysarthria scores were significantly altered compared to healthy controls. Moreover, the EDSS scores were correlated with the maximum expiratory times; the maximum expiratory times were correlated with the maximum phonation times, and the maximum phonation times were correlated with the dysarthria scores. Conclusions: As the expiratory times were significantly correlated with the EDSS scores, they could be used to measure the severity of MS and to monitor its progression.
Lingua originaleEnglish
pagine (da-a)27-32
Numero di pagine6
RivistaMultiple Sclerosis and Related Disorders
Volume23
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Dysarthria
  • Phonation
  • Multiple Sclerosis
  • Speech disorders
  • Speech evaluation methods
  • Adult
  • Aged
  • Case-Control Studies
  • Disability Evaluation
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis, Chronic Progressive
  • Severity of Illness Index
  • Time Factors
  • Exhalation
  • EDSS

Fingerprint Entra nei temi di ricerca di 'Expiratory and phonation times as measures of disease severity in patients with Multiple Sclerosis. A case-control study'. Insieme formano una fingerprint unica.

Cita questo