Expert consensus on dynamics of laboratory tests for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis

Donato Rigante, Angelo Ravelli, Francesca Minoia, Sergio Davì, Annacarin Horne, Francesca Bovis, Angela Pistorio, Maurizio Aricò, Tadej Avcin, Edward M Behrens, Fabrizio De Benedetti, Alexandra Filipovic, Alexei A Grom, Jan-Inge Henter, Norman T Ilowite, Michael B Jordan, Raju Khubchandani, Toshiyuki Kitoh, Kai Lehmberg, Daniel J LovellPaivi Miettunen, Kim E Nichols, Seza Ozen, Jana Pachlopnik Schmid, Athimalaipet V Ramanan, Ricardo Russo, Rayfel Schneider, Gary Sterba, Yosef Uziel, Carol Wallace, Carine Wouters, Nico Wulffraat, Erkan Demirkaya, Hermine I Brunner, Alberto Martini, Nicolino Ruperto, Randy Q Cron, Simona Angioloni, Chiara Pallotti, Michele Pesce, Mariangela Rinaldi, Luca Villa, Mario Abinun, Amita Aggarwal, Jonathan Akikusa, Sulaiman M Al-Mayouf, Maria Alessio, Jordi Anton, Maria Teresa Apaz, Itziar Astigarraga, Nuray A Ayaz, Patrizia Barone, Blanca Bica, Isabel Bolt, Luciana Breda, Vyacheslav Chasnyk, Rolando Cimaz, Fabrizia Corona, Ruben Cuttica, Gianfranco D'Angelo, Zane Davidsone, Carmen De Cunto, Jaime De Inocencio, Eli Eisenstein, Sandra Enciso, Graciela Espada, Michel Fischbach, Michael Frosch, Romina Gallizzi, Maria Luz Gamir, Yi-Jin Gao, Thomas Griffin, Soad Hashad, Teresa Hennon, Gerd Horneff, Zeng Huasong, Adam Huber, Antonella Insalaco, Maka Ioseliani, Marijia Jelusic-Drazic, Michael Jeng, Agneza Kapovic, Ozgur Kasapcopur, Isabelle Kone-Paut, Sheila Knupp Feitosa De Oliveira, Bianca Lattanzi, Loredana Lepore, Caifeng Li, Jeffrey M Lipton, Silvia Magni-Manzoni, Despoina Maritsi, Deborah Mccurdy, Rosa Merino, Velma Mulaosmanovic, Susan Nielsen, Priyankar Pal, Sampath Prahalad, Ingrida Rumba-Rozenfelde, Claudia Saad Magalhaes, Helga Sanner, Sujata Sawhney, Wafaa M Sewairi, Bita Shakoory, Susan Shenoi, Artur Silva Clovis, Valda Stanevicha, Kimo C Stine, Gordana Susic, Flavio Sztajnbok, Syuji Takei, Hasan Tezer, Ralf Trauzeddel, Elena Tsitsami, Erbil Unsal, Olga Vougiouka, Lehn K Weaver, Jennifer Weiss, Sheila Weitzman, Mabruka Zletni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

35 Citazioni (Scopus)

Abstract

Objective: To identify which laboratory tests that change over time are most valuable for the timely diagnosis of macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (sJIA). Methods: A multistep process, based on a combination of expert consensus and analysis of real patient data, was conducted. A panel of experts was first asked to evaluate 115 profiles of patients with MAS, which included the values of laboratory tests at the pre-MAS visit and at MAS onset, and the change in values between the two time points. The experts were asked to choose the 5 laboratory tests in which change was most important for the diagnosis of MAS and to rank the 5 selected tests in order of importance. The relevance of change in laboratory parameters was further discussed and ranked by the same experts at a consensus conference. Results: Platelet count was the most frequently selected test, followed by ferritin level, aspartate aminotransferase (AST), white cell count, neutrophil count, and fibrinogen and erythrocyte sedimentation rate. Ferritin was most frequently assigned the highest score. At the end of the process, platelet count, ferritin level and AST were the laboratory tests in which the experts found change over time to be most important. Conclusions: We identified the laboratory tests in which change over time is most valuable for the early diagnosis of MAS in sJIA. The dynamics of laboratory values during the course of MAS should be further scrutinised in a prospective study in order to establish the optimal cut-off values for their variation.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaRMD Open
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Macrophage activation syndrome

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