Experimental approaches for studying semaphorin signals in tumor growth and metastasis in mouse models

Luca Tamagnone, Enrico Moiso, Massimo Accardo

Risultato della ricerca: Contributo in libroChapter

Abstract

Tumor growth and metastatic dissemination are complex multistep processes. They clearly depend on the intrinsic behavior of cancer cells, but are remarkably influenced by a variety of stromal cells present in the tumor microenvironment, which include those implicated in tumor angiogenesis, as well as bone marrow-derived cells recruited from the circulation. Moreover, multiple molecular signals exchanged between cancer cells and non-neoplastic stromal cells control tumor growth and metastasis; notably, members of the semaphorin family are emerging players in this scenario. In vivo tumor models represent the best setting for studying metastatic tumor progression, as they allow recapitulating the contribution of multiple cell types and signaling molecules in a complex tissue context, subject to pathophysiological local and systemic responses, such as metabolic changes, hypoxia, necrosis, fibrosis, inflammation, and cytokine release. Here, we describe some experimental approaches based on murine models to study the role of semaphorin signaling in tumor growth and metastatic progression in vivo.
Lingua originaleEnglish
Titolo della pubblicazione ospiteSemaphorin Signaling
Pagine467-484
Numero di pagine18
DOI
Stato di pubblicazionePubblicato - 2017

Serie di pubblicazioni

NomeMETHODS IN MOLECULAR BIOLOGY

Keywords

  • Animals
  • Cancer biology
  • Disease Models, Animal
  • Genetics
  • In vivo models
  • Metastasis
  • Mice
  • Molecular Biology
  • Mouse models
  • Neoplasm Metastasis
  • Neoplasms
  • Plexins
  • Semaphorins
  • Signal Transduction

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