Ex Vivo lung sonography: morphologic-ultrasound relationship

Gino Soldati, Riccardo Inchingolo, Andrea Smargiassi, Sara Sher, Rosanna Nenna, Cosimo Damiano Inchingolo, Salvatore Valente

Risultato della ricerca: Contributo in rivistaArticolo in rivista

62 Citazioni (Scopus)


Ultrasound (US) interstitial syndrome is a sonographic lung pattern characterized by the presence of acoustic artifacts (B-lines and white lung). The purpose of this study was to demonstrate how interstitial syndrome is determined by acoustic interactions in lungs of variable density and in healthy organs deflated to a nonphysiologic level of density. Normal rabbit lungs were studied ex vivo by US at varying known degrees of inflation, and their histologic appearances were described. In this experimental setting, US interstitial syndrome recognizes a mechanism related to tissue density or porosity. Artifacts (B-lines and white lung) appear in the normal rabbit lung through air-dependent increases in density. As in pathologic conditions, US interstitial syndrome can be reproduced in histologically normal lungs that are deflated to a critical level (>0.45 g/mL) of density, which is not achievable under physiologic conditions.
Lingua originaleEnglish
pagine (da-a)1169-1179
Numero di pagine11
RivistaUltrasound in Medicine and Biology
Stato di pubblicazionePubblicato - 2012
Pubblicato esternamente


  • Chest sonography
  • Lung US/histologic relationship
  • Lung density
  • Porosity
  • Ultrasound lung artifacts


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