Ex vivo gene therapy using autologous dermal fibroblasts expressing hLMP3 for rat mandibular bone regeneration

Claudio Parrilla; Wanda Lattanzi; Francesco Bussu; Enrico Pola; Gaetano Paludetti

doi:10.1002/hed.21185

Ex vivo gene therapy using autologous dermal fibroblasts expressing hLMP3 for rat mandibular bone regeneration

Claudio Parrilla, Wanda Lattanzi, Francesco Bussu, Enrico Pola, Gaetano Paludetti

Risultato della ricerca: Contributo in rivista › Articolo in rivista

23 Citazioni (Scopus)

Abstract

Implantation of autologous skin fibroblasts transduced ex vivo with a replication-defective adenoviral vector, carrying the LIM mineralization protein-3 (Ad-LMP-3), and adsorbed on a hydroxyapatite/collagen (HA/COL) scaffold.

Lingua originale	English
pagine (da-a)	310-318
Numero di pagine	9
Rivista	HEAD & NECK
Volume	32
DOI	https://doi.org/10.1002/hed.21185
Stato di pubblicazione	Pubblicato - 2010

Keywords

Animals
Biocompatible Materials
Bone Regeneration
Collagen
Dermis
Durapatite
Fibroblasts
Gene Therapy
Guided Tissue Regeneration
Homeodomain Proteins
LIM-Homeodomain Proteins
Mandible
Osteogenesis
Rats
Rats, Wistar
Tissue Scaffolds
Transcription Factors
Transduction, Genetic

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10.1002/hed.21185

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title = "Ex vivo gene therapy using autologous dermal fibroblasts expressing hLMP3 for rat mandibular bone regeneration",

abstract = "Implantation of autologous skin fibroblasts transduced ex vivo with a replication-defective adenoviral vector, carrying the LIM mineralization protein-3 (Ad-LMP-3), and adsorbed on a hydroxyapatite/collagen (HA/COL) scaffold.",

keywords = "Animals, Biocompatible Materials, Bone Regeneration, Collagen, Dermis, Durapatite, Fibroblasts, Gene Therapy, Guided Tissue Regeneration, Homeodomain Proteins, LIM-Homeodomain Proteins, Mandible, Osteogenesis, Rats, Rats, Wistar, Tissue Scaffolds, Transcription Factors, Transduction, Genetic, Animals, Biocompatible Materials, Bone Regeneration, Collagen, Dermis, Durapatite, Fibroblasts, Gene Therapy, Guided Tissue Regeneration, Homeodomain Proteins, LIM-Homeodomain Proteins, Mandible, Osteogenesis, Rats, Rats, Wistar, Tissue Scaffolds, Transcription Factors, Transduction, Genetic",

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doi = "10.1002/hed.21185",

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T1 - Ex vivo gene therapy using autologous dermal fibroblasts expressing hLMP3 for rat mandibular bone regeneration

AU - Parrilla, Claudio

AU - Lattanzi, Wanda

AU - Bussu, Francesco

AU - Pola, Enrico

AU - Paludetti, Gaetano

PY - 2010

Y1 - 2010

N2 - Implantation of autologous skin fibroblasts transduced ex vivo with a replication-defective adenoviral vector, carrying the LIM mineralization protein-3 (Ad-LMP-3), and adsorbed on a hydroxyapatite/collagen (HA/COL) scaffold.

AB - Implantation of autologous skin fibroblasts transduced ex vivo with a replication-defective adenoviral vector, carrying the LIM mineralization protein-3 (Ad-LMP-3), and adsorbed on a hydroxyapatite/collagen (HA/COL) scaffold.

KW - Animals

KW - Biocompatible Materials

KW - Bone Regeneration

KW - Collagen

KW - Dermis

KW - Durapatite

KW - Fibroblasts

KW - Gene Therapy

KW - Guided Tissue Regeneration

KW - Homeodomain Proteins

KW - LIM-Homeodomain Proteins

KW - Mandible

KW - Osteogenesis

KW - Rats

KW - Rats, Wistar

KW - Tissue Scaffolds

KW - Transcription Factors

KW - Transduction, Genetic

KW - Animals

KW - Biocompatible Materials

KW - Bone Regeneration

KW - Collagen

KW - Dermis

KW - Durapatite

KW - Fibroblasts

KW - Gene Therapy

KW - Guided Tissue Regeneration

KW - Homeodomain Proteins

KW - LIM-Homeodomain Proteins

KW - Mandible

KW - Osteogenesis

KW - Rats

KW - Rats, Wistar

KW - Tissue Scaffolds

KW - Transcription Factors

KW - Transduction, Genetic

UR - http://hdl.handle.net/10807/26453

U2 - 10.1002/hed.21185

DO - 10.1002/hed.21185

M3 - Article

SN - 1097-0347

VL - 32

SP - 310

EP - 318

JO - HEAD & NECK

JF - HEAD & NECK

ER -

Ex vivo gene therapy using autologous dermal fibroblasts expressing hLMP3 for rat mandibular bone regeneration

Abstract

Keywords

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