TY - JOUR
T1 - Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010.
AU - Colafigli, Manuela
AU - Torti, Carlo
AU - Trecarichi, Enrico Maria
AU - Albini, L.
AU - Rosi, A.
AU - Micheli, V.
AU - Manca, N.
AU - Penco, G.
AU - Bruzzone, B.
AU - Punzi, G.
AU - Corsi, P.
AU - Parruti, G.
AU - Bagnarelli, P.
AU - Monno, L.
AU - Gonnelli, A.
AU - Cauda, Roberto
AU - Di Giambenedetto, Simona
PY - 2012
Y1 - 2012
N2 - Prevalence and predictors of transmitted drug resistance (TDR),
defined as the presence of at least one WHO surveillance drug
resistance mutation (SDRM), were investigated in antiretroviral naı
¨ve HIV-1-infected patients, with a genotypic resistance test
(GRT) performed £6 months before starting cART between
2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype
B). Overall, the prevalence of TDR was 12% (13.2% subtype
B, 9% non-B). TDR significantly declined overall and for the
single drug classes. Older age independently predicted increased
odds of TDR, whereas a more recent GRT, a higher HIV-RNA
AB - Prevalence and predictors of transmitted drug resistance (TDR),
defined as the presence of at least one WHO surveillance drug
resistance mutation (SDRM), were investigated in antiretroviral naı
¨ve HIV-1-infected patients, with a genotypic resistance test
(GRT) performed £6 months before starting cART between
2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype
B). Overall, the prevalence of TDR was 12% (13.2% subtype
B, 9% non-B). TDR significantly declined overall and for the
single drug classes. Older age independently predicted increased
odds of TDR, whereas a more recent GRT, a higher HIV-RNA
KW - HAART
KW - HIV
KW - HAART
KW - HIV
UR - http://hdl.handle.net/10807/29003
U2 - 10.1111/j.1469-0691.2012.03847.x
DO - 10.1111/j.1469-0691.2012.03847.x
M3 - Article
SN - 1198-743X
SP - 299
EP - 304
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
ER -
