Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010.

Manuela Colafigli; Carlo Torti; Enrico Maria Trecarichi; Laura Albini; Andrea Rosi; Valeria Micheli; Nino Manca; Giovanni Penco; Bianca Bruzzone; Grazia Punzi; Paola Corsi; Giustino Parruti; Patrizia Bagnaelli; Laura Monno; Angela Gonnelli; Roberto Cauda; Simona Di Giambenedetto

Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010.

Manuela Colafigli, Carlo Torti, Enrico Maria Trecarichi, Laura Albini, Andrea Rosi, Valeria Micheli, Nino Manca, Giovanni Penco, Bianca Bruzzone, Grazia Punzi, Paola Corsi, Giustino Parruti, Patrizia Bagnaelli, Laura Monno, Angela Gonnelli, Roberto Cauda, Simona Di Giambenedetto

Risultato della ricerca: Contributo in rivista › Articolo in rivista

24 Citazioni (Scopus)

Abstract

Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral naı ¨ve HIV-1-infected patients, with a genotypic resistance test (GRT) performed £6 months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA

Lingua originale	English
pagine (da-a)	299-304
Numero di pagine	6
Rivista	Clinical Microbiology and Infection
Stato di pubblicazione	Pubblicato - 2012

Keywords

HAART
HIV

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Colafigli, M., Torti, C., Trecarichi, E. M., Albini, L., Rosi, A., Micheli, V., Manca, N., Penco, G., Bruzzone, B., Punzi, G., Corsi, P., Parruti, G., Bagnaelli, P., Monno, L., Gonnelli, A., Cauda, R., & Di Giambenedetto, S. (2012). Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010. Clinical Microbiology and Infection, 299-304.

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abstract = "Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral naı ¨ve HIV-1-infected patients, with a genotypic resistance test (GRT) performed £6 months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA",

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author = "Manuela Colafigli and Carlo Torti and Trecarichi, {Enrico Maria} and Laura Albini and Andrea Rosi and Valeria Micheli and Nino Manca and Giovanni Penco and Bianca Bruzzone and Grazia Punzi and Paola Corsi and Giustino Parruti and Patrizia Bagnaelli and Laura Monno and Angela Gonnelli and Roberto Cauda and {Di Giambenedetto}, Simona",

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language = "English",

pages = "299--304",

journal = "Clinical Microbiology and Infection",

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TY - JOUR

T1 - Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010.

AU - Colafigli, Manuela

AU - Torti, Carlo

AU - Trecarichi, Enrico Maria

AU - Albini, Laura

AU - Rosi, Andrea

AU - Micheli, Valeria

AU - Manca, Nino

AU - Penco, Giovanni

AU - Bruzzone, Bianca

AU - Punzi, Grazia

AU - Corsi, Paola

AU - Parruti, Giustino

AU - Bagnaelli, Patrizia

AU - Monno, Laura

AU - Gonnelli, Angela

AU - Cauda, Roberto

AU - Di Giambenedetto, Simona

PY - 2012

Y1 - 2012

N2 - Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral naı ¨ve HIV-1-infected patients, with a genotypic resistance test (GRT) performed £6 months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA

AB - Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral naı ¨ve HIV-1-infected patients, with a genotypic resistance test (GRT) performed £6 months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA

KW - HAART

KW - HIV

KW - HAART

KW - HIV

UR - http://hdl.handle.net/10807/29003

M3 - Article

SN - 1198-743X

SP - 299

EP - 304

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

ER -

Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010.

Abstract

Keywords

OSS delle Nazioni Unite

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