Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010.

Roberto Cauda, Simona Di Giambenedetto, Manuela Colafigli, Enrico Maria Trecarichi, Carlo Torti, Laura Albini, Andrea Rosi, Valeria Micheli, Nino Manca, Giovanni Penco, Bianca Bruzzone, Grazia Punzi, Paola Corsi, Giustino Parruti, Patrizia Bagnaelli, Laura Monno, Angela Gonnelli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

23 Citazioni (Scopus)

Abstract

Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral naı ¨ve HIV-1-infected patients, with a genotypic resistance test (GRT) performed £6 months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA
Lingua originaleEnglish
pagine (da-a)299-304
Numero di pagine6
RivistaClinical Microbiology and Infection
Stato di pubblicazionePubblicato - 2012

Keywords

  • HAART
  • HIV

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