Evidence of involvement of leptin and IL-6 peptides in the action of interferon-beta in secondary progressive multiple sclerosis

Massimiliano Mirabella, Giovanni Frisullo, Agata Katia Patanella, Cristina Sancricca, Viviana Nociti, Anna Paola Batocchi, F Angelucci, Marcella Caggiula, Pietro Attilio Tonali

Risultato della ricerca: Contributo in rivistaArticolo in rivista

11 Citazioni (Scopus)

Abstract

Leptin is a peptide hormone which acts on cells of immune system by influencing the production of cytokines. Serum leptin levels and cytokine production by peripheral blood mononuclear cells (PBMC) were measured in 18 secondary progressive multiple sclerosis (SPMS) patients under IFN-beta-1b treatment. There were no overall effects on leptin, interleukin-6 (IL-6), IL-10 and IL-12 p40 after 2, 6 and 12 months of treatment. However, leptin and IL-6 decreased after 6 and 12 months of treatment in 12 patients who did not show progression of disability. Thus, our pilot data show that the beneficial effect of IFN-beta on some SPMS patients might be associated with the reduced levels of leptin and reduced IL-6 production by PBMC.
Lingua originaleEnglish
pagine (da-a)2289-2293
Numero di pagine5
RivistaPeptides
Volume26
DOI
Stato di pubblicazionePubblicato - 2005

Keywords

  • Interleukin-6
  • Leptin
  • Multiple Sclerosis, Chronic Progressive

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