TY - JOUR
T1 - Everolimus-induced epithelial to mesenchymal transition in immortalized human renal proximal tubular epithelial cells: key role of heparanase
AU - Masola, V
AU - Zaza, G
AU - Granata, S
AU - Gambaro, Giovanni
AU - Onisto, M
AU - Lupo, A.
PY - 2013
Y1 - 2013
N2 - Everolimus (EVE) is a drug widely used in several renal transplant protocols. Although characterized by a relatively low nephrotoxicity, it may induce several adverse effects including severe fibro-interstitial pneumonitis. The exact molecular/biological mechanism associated to these pro-fibrotic effects is unknown, but epithelial to mesenchymal transition (EMT) may have a central role. Additionally, heparanase, an enzyme recently associated with the progression of chronic allograft nephropathy, could contribute to activate this machinery in renal cells.
AB - Everolimus (EVE) is a drug widely used in several renal transplant protocols. Although characterized by a relatively low nephrotoxicity, it may induce several adverse effects including severe fibro-interstitial pneumonitis. The exact molecular/biological mechanism associated to these pro-fibrotic effects is unknown, but epithelial to mesenchymal transition (EMT) may have a central role. Additionally, heparanase, an enzyme recently associated with the progression of chronic allograft nephropathy, could contribute to activate this machinery in renal cells.
KW - everolimus
KW - renal tubular cell
KW - everolimus
KW - renal tubular cell
UR - https://publicatt.unicatt.it/handle/10807/52202
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84887730300&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84887730300&origin=inward
U2 - 10.1186/1479-5876-11-292
DO - 10.1186/1479-5876-11-292
M3 - Article
SN - 1479-5876
VL - 11
SP - 292
EP - 292
JO - Journal of Translational Medicine
JF - Journal of Translational Medicine
IS - 1
ER -