Everolimus-induced epithelial to mesenchymal transition in immortalized human renal proximal tubular epithelial cells: key role of heparanase

Giovanni Gambaro, Valentina Masola, Gianluigi Zaza, Simona Granata, Maurizio Onisto, Antonio Lupo

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

16 Citazioni (Scopus)

Abstract

Everolimus (EVE) is a drug widely used in several renal transplant protocols. Although characterized by a relatively low nephrotoxicity, it may induce several adverse effects including severe fibro-interstitial pneumonitis. The exact molecular/biological mechanism associated to these pro-fibrotic effects is unknown, but epithelial to mesenchymal transition (EMT) may have a central role. Additionally, heparanase, an enzyme recently associated with the progression of chronic allograft nephropathy, could contribute to activate this machinery in renal cells.
Lingua originaleEnglish
pagine (da-a)292-292
Numero di pagine1
RivistaJournal of Translational Medicine
Volume11
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • everolimus
  • renal tubular cell

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