Evaluation of the prevalence of severe hyperhomocysteinemia in adult patients with thrombosis who underwent screening for thrombophilia

Valerio De Stefano, Silvia Betti, Federico Lussana, Armando D'Angelo, Sandra Fedi, Paola Ferrazzi, Cristina Legnani, Rossella Marcucci, Gualtiero Palareti, Lidia L. Rota, Francesca Sampietro, Alessandro Squizzato, Domenico Prisco, Marco Cattaneo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

12 Citazioni (Scopus)

Abstract

Treatment with B-vitamins and betaine reduces the high risk of thrombosis in patients with homocystinuria, a metabolic syndrome that is characterized by severe hyperhomocysteinemia (HHcy). In contrast, there is no clear demonstration that B-vitamins reduce the risk of thrombosis in patients with mild HHcy: for this reason, many question the clinical utility of measuring total Hcy (tHcy) in patients with thrombosis. However, thrombosis may be the first clinical manifestation of homocystinuria in patients reaching adulthood without signs and symptoms of the syndrome.
Lingua originaleEnglish
pagine (da-a)681-684
Numero di pagine4
RivistaThrombosis Research
Volume132
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • CBS
  • CI
  • Confidence Intervals
  • HHCy
  • Hcy
  • Homocysteine
  • Homocystinuria
  • Hyperhomocysteinemia
  • MTHFR
  • Thrombophilia
  • Thrombosis
  • cystathionine β-synthase
  • homocysteine
  • hyperhomocysteine
  • methylene tethrahydrofolate reductase
  • tHcy
  • total homocysteine

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