Evaluation of efficacy, pharmacokinetics and tolerability of peptidomimetic aspartic proteinase inhibitors as cream formulation in experimental vaginal candidiasis

Flavia De Bernardis; Silvia Arancia; Giuseppe Tringali; Maria Cristina Greco; Enzo Ragazzoni; Chiara Calugi; Andrea Trabocchi; Silvia Sandini; Sofia Graziani; Roberto Cauda; Antonio Cassone; Antonio Guarna; Pierluigi Navarra

doi:10.1111/jphp.12240

Evaluation of efficacy, pharmacokinetics and tolerability of peptidomimetic aspartic proteinase inhibitors as cream formulation in experimental vaginal candidiasis

Flavia De Bernardis
, Silvia Arancia
, Giuseppe Tringali
, Maria Cristina Greco
, Enzo Ragazzoni
, Chiara Calugi
, Andrea Trabocchi
, Silvia Sandini
, Sofia Graziani
, Roberto Cauda
, Antonio Cassone
, Antonio Guarna
, Pierluigi Navarra

Istituto Superiore di Sanita

Risultato della ricerca: Contributo in rivista › Articolo

6 Citazioni (Scopus)

Abstract

It has been previously shown that the treatment with the two protease inhibitors APG12 and APG19 confers protection in a rat model of mucosal candidiasis; in this study, we examined whether these peptidomimetic inhibitors are also effective as a cream formulation in reducing Candida albicans vaginal infection.

Lingua originale	Inglese
pagine (da-a)	1094-1101
Numero di pagine	8
Rivista	Journal of Pharmacy and Pharmacology
DOI	https://doi.org/10.1111/jphp.12240
Stato di pubblicazione	Pubblicato - 2014

Keywords

peptidomimetics
secreted aspartic proteinase inhibitors
vaginal experimental candidiasis

Accesso al documento

10.1111/jphp.12240

Altri file e collegamenti

Link a IRIS PubliCatt

Cita questo

De Bernardis, F., Arancia, S., Tringali, G., Greco, M. C., Ragazzoni, E., Calugi, C., Trabocchi, A., Sandini, S., Graziani, S., Cauda, R., Cassone, A., Guarna, A., & Navarra, P. (2014). Evaluation of efficacy, pharmacokinetics and tolerability of peptidomimetic aspartic proteinase inhibitors as cream formulation in experimental vaginal candidiasis. Journal of Pharmacy and Pharmacology, 1094-1101. https://doi.org/10.1111/jphp.12240

@article{adcc2bae86d24f33aa4d0d767a4fd9e7,

title = "Evaluation of efficacy, pharmacokinetics and tolerability of peptidomimetic aspartic proteinase inhibitors as cream formulation in experimental vaginal candidiasis",

abstract = "It has been previously shown that the treatment with the two protease inhibitors APG12 and APG19 confers protection in a rat model of mucosal candidiasis; in this study, we examined whether these peptidomimetic inhibitors are also effective as a cream formulation in reducing Candida albicans vaginal infection.",

keywords = "peptidomimetics, secreted aspartic proteinase inhibitors, vaginal experimental candidiasis, peptidomimetics, secreted aspartic proteinase inhibitors, vaginal experimental candidiasis",

author = "\{De Bernardis\}, Flavia and Silvia Arancia and Giuseppe Tringali and Greco, \{Maria Cristina\} and Enzo Ragazzoni and Chiara Calugi and Andrea Trabocchi and Silvia Sandini and Sofia Graziani and Roberto Cauda and Antonio Cassone and Antonio Guarna and Pierluigi Navarra",

year = "2014",

doi = "10.1111/jphp.12240",

language = "English",

pages = "1094--1101",

journal = "Journal of Pharmacy and Pharmacology",

issn = "0022-3573",

}

De Bernardis, F, Arancia, S, Tringali, G, Greco, MC, Ragazzoni, E, Calugi, C, Trabocchi, A, Sandini, S, Graziani, S, Cauda, R, Cassone, A, Guarna, A & Navarra, P 2014, 'Evaluation of efficacy, pharmacokinetics and tolerability of peptidomimetic aspartic proteinase inhibitors as cream formulation in experimental vaginal candidiasis', Journal of Pharmacy and Pharmacology, pagg. 1094-1101. https://doi.org/10.1111/jphp.12240

TY - JOUR

T1 - Evaluation of efficacy, pharmacokinetics and tolerability of peptidomimetic aspartic proteinase inhibitors as cream formulation in experimental vaginal candidiasis

AU - De Bernardis, Flavia

AU - Arancia, Silvia

AU - Tringali, Giuseppe

AU - Greco, Maria Cristina

AU - Ragazzoni, Enzo

AU - Calugi, Chiara

AU - Trabocchi, Andrea

AU - Sandini, Silvia

AU - Graziani, Sofia

AU - Cauda, Roberto

AU - Cassone, Antonio

AU - Guarna, Antonio

AU - Navarra, Pierluigi

PY - 2014

Y1 - 2014

N2 - It has been previously shown that the treatment with the two protease inhibitors APG12 and APG19 confers protection in a rat model of mucosal candidiasis; in this study, we examined whether these peptidomimetic inhibitors are also effective as a cream formulation in reducing Candida albicans vaginal infection.

AB - It has been previously shown that the treatment with the two protease inhibitors APG12 and APG19 confers protection in a rat model of mucosal candidiasis; in this study, we examined whether these peptidomimetic inhibitors are also effective as a cream formulation in reducing Candida albicans vaginal infection.

KW - peptidomimetics

KW - secreted aspartic proteinase inhibitors

KW - vaginal experimental candidiasis

KW - peptidomimetics

KW - secreted aspartic proteinase inhibitors

KW - vaginal experimental candidiasis

UR - http://hdl.handle.net/10807/60688

U2 - 10.1111/jphp.12240

DO - 10.1111/jphp.12240

M3 - Article

SN - 0022-3573

SP - 1094

EP - 1101

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

ER -

Evaluation of efficacy, pharmacokinetics and tolerability of peptidomimetic aspartic proteinase inhibitors as cream formulation in experimental vaginal candidiasis

Abstract

Keywords

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo