Evaluation of efficacy, pharmacokinetics and tolerability of peptidomimetic aspartic proteinase inhibitors as cream formulation in experimental vaginal candidiasis

Giuseppe Tringali, Roberto Cauda, Pierluigi Navarra, Silvia Arancia, Maria Cristina Greco, Enzo Ragazzoni, Flavia De Bernardis, Chiara Calugi, Andrea Trabocchi, Silvia Sandini, Sofia Graziani, Antonio Cassone, Antonio Guarna

Risultato della ricerca: Contributo in rivistaArticolo in rivista

6 Citazioni (Scopus)

Abstract

It has been previously shown that the treatment with the two protease inhibitors APG12 and APG19 confers protection in a rat model of mucosal candidiasis; in this study, we examined whether these peptidomimetic inhibitors are also effective as a cream formulation in reducing Candida albicans vaginal infection.
Lingua originaleEnglish
pagine (da-a)1094-1101
Numero di pagine8
RivistaJOURNAL OF PHARMACY AND PHARMACOLOGY
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • peptidomimetics
  • secreted aspartic proteinase inhibitors
  • vaginal experimental candidiasis

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