Evaluating antirheumatic treatments using synovial biopsy: A recommendation for standardisation to be used in clinical trials

Stefano Alivernini, Marleen G. H. Van De Sande, Danielle M. Gerlag, Beatrijs M. Lodde, Lisa G. M. Van Baarsen, Veronica Codullo, Ioana Felea, Elsa Vieira-Sousa, Ursula Fearon, Richard Reece, Carlomaurizio Montecucco, Douglas J. Veale, Costantino Pitzalis, Paul Emery, Lars Klareskog, Iain B. Mcinnes, Paul P. Tak

Risultato della ricerca: Contributo in rivistaArticolo in rivista

85 Citazioni (Scopus)

Abstract

Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and mechanistic evaluation of antirheumatic treatments. In addition, studies are ongoing, aimed at the identification of diagnostic and prognostic biomarkers in the synovium. This paper outlines the currently used procedures for sampling and processing of synovial tissue, and presents a standardised recommendation to support multicentre translational research.
Lingua originaleEnglish
pagine (da-a)423-427
Numero di pagine5
RivistaANNALS OF THE RHEUMATIC DISEASES
Volume70
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Antirheumatic Agents
  • Arthritis, Rheumatoid
  • Arthroscopy
  • Biochemistry, Genetics and Molecular Biology (all)
  • Biopsy
  • Clinical Trials as Topic
  • Humans
  • Immunology
  • Immunology and Allergy
  • Knee Joint
  • Multicenter Studies as Topic
  • Rheumatology
  • Synovial Membrane
  • Synovitis
  • Treatment Outcome
  • Ultrasonography, Interventional

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