TY - JOUR
T1 - Evaluating antirheumatic treatments using synovial biopsy: A recommendation for standardisation to be used in clinical trials
AU - Van De Sande, Marleen G. H.
AU - Gerlag, Danielle M.
AU - Lodde, Beatrijs M.
AU - Van Baarsen, Lisa G. M.
AU - Alivernini, Stefano
AU - Codullo, Veronica
AU - Felea, Ioana
AU - Vieira-Sousa, Elsa
AU - Fearon, Ursula
AU - Reece, Richard
AU - Montecucco, Carlomaurizio
AU - Veale, Douglas J.
AU - Pitzalis, Costantino
AU - Emery, Paul
AU - Klareskog, Lars
AU - Mcinnes, Iain B.
AU - Tak, Paul P.
PY - 2011
Y1 - 2011
N2 - Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and mechanistic evaluation of antirheumatic treatments. In addition, studies are ongoing, aimed at the identification of diagnostic and prognostic biomarkers in the synovium. This paper outlines the currently used procedures for sampling and processing of synovial tissue, and presents a standardised recommendation to support multicentre translational research.
AB - Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and mechanistic evaluation of antirheumatic treatments. In addition, studies are ongoing, aimed at the identification of diagnostic and prognostic biomarkers in the synovium. This paper outlines the currently used procedures for sampling and processing of synovial tissue, and presents a standardised recommendation to support multicentre translational research.
KW - Antirheumatic Agents
KW - Arthritis, Rheumatoid
KW - Arthroscopy
KW - Biochemistry, Genetics and Molecular Biology (all)
KW - Biopsy
KW - Clinical Trials as Topic
KW - Humans
KW - Immunology
KW - Immunology and Allergy
KW - Knee Joint
KW - Multicenter Studies as Topic
KW - Rheumatology
KW - Synovial Membrane
KW - Synovitis
KW - Treatment Outcome
KW - Ultrasonography, Interventional
KW - Antirheumatic Agents
KW - Arthritis, Rheumatoid
KW - Arthroscopy
KW - Biochemistry, Genetics and Molecular Biology (all)
KW - Biopsy
KW - Clinical Trials as Topic
KW - Humans
KW - Immunology
KW - Immunology and Allergy
KW - Knee Joint
KW - Multicenter Studies as Topic
KW - Rheumatology
KW - Synovial Membrane
KW - Synovitis
KW - Treatment Outcome
KW - Ultrasonography, Interventional
UR - http://hdl.handle.net/10807/114738
UR - http://ard.bmj.com/content/70/3/423.full.pdf
U2 - 10.1136/ard.2010.139550
DO - 10.1136/ard.2010.139550
M3 - Article
SN - 0003-4967
VL - 70
SP - 423
EP - 427
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
ER -