TY - JOUR
T1 - European guidelines on the clinical management of HIV-1 tropism testing
AU - Vandekerckhove, Linos
AU - Wensing, Annemarie
AU - Kaiser, Rolf
AU - Brun Vezinet, Francoise
AU - Clotet, Bonaventura
AU - De Luca, Andrea
AU - Dressler, Stephan
AU - Garcia, Federico
AU - Geretti, Anna Maria
AU - Klimkait, Thomas
AU - Korn, Klaus
AU - Masquelier, Bernard
AU - Perno, Carlo Federico
AU - Shapiro, Jonathan
AU - Soriano, Vincent
AU - Sonnerborg, Anders
AU - Vandamme, Anne Meke
AU - Verhofstede, Chris
AU - Walter, Hauke
AU - Zazzi, Maurizio
AU - Boucher, Charles
AU - European Consensus Group, Management Of Tropism Testing
PY - 2011
Y1 - 2011
N2 - Viral tropism is the ability of viruses to enter and infect specifi c host cells and is based on the ability of viruses to bind to receptors on those cells. Testing for HIV tropism is recommended before prescribing a chemokine receptor blocker. In most European countries, HIV tropism is identifi ed with tropism phenotype testing. New data support genotype analysis of the HIV third hypervariable loop (V3) for the identifi cation of tropism. The European Consensus Group on clinical management of tropism testing was established to make recommendations to clinicians and clinical virologists. The panel recommends HIV-tropism testing for the following groups: drug-naive patients in whom toxic eff ects are anticipated or for whom few treatment options are available; patients who have poor tolerability to or toxic eff ects from current treatment or who have CNS pathology; and patients for whom therapy has failed and a change in treatment is considered. In general, an enhanced sensitivity Trofi le assay and V3 population genotyping are the recommended methods. Genotypic methods are anticipated to be used more frequently in the clinical setting because of their greater accessibility, lower cost, and faster turnaround time than other methods. For the interpretation of V3 loop genotyping, clinically validated systems should be used when possible. Laboratories doing HIV tropism
tests should have adequate quality assurance measures. Similarly, close collaboration between HIV clinicians and virologists is needed to ensure adequate diagnostic and treatment decisions.
AB - Viral tropism is the ability of viruses to enter and infect specifi c host cells and is based on the ability of viruses to bind to receptors on those cells. Testing for HIV tropism is recommended before prescribing a chemokine receptor blocker. In most European countries, HIV tropism is identifi ed with tropism phenotype testing. New data support genotype analysis of the HIV third hypervariable loop (V3) for the identifi cation of tropism. The European Consensus Group on clinical management of tropism testing was established to make recommendations to clinicians and clinical virologists. The panel recommends HIV-tropism testing for the following groups: drug-naive patients in whom toxic eff ects are anticipated or for whom few treatment options are available; patients who have poor tolerability to or toxic eff ects from current treatment or who have CNS pathology; and patients for whom therapy has failed and a change in treatment is considered. In general, an enhanced sensitivity Trofi le assay and V3 population genotyping are the recommended methods. Genotypic methods are anticipated to be used more frequently in the clinical setting because of their greater accessibility, lower cost, and faster turnaround time than other methods. For the interpretation of V3 loop genotyping, clinically validated systems should be used when possible. Laboratories doing HIV tropism
tests should have adequate quality assurance measures. Similarly, close collaboration between HIV clinicians and virologists is needed to ensure adequate diagnostic and treatment decisions.
KW - tropism testing
KW - tropism testing
UR - http://hdl.handle.net/10807/5691
M3 - Article
SN - 1473-3099
VL - 11
SP - 394
EP - 407
JO - The Lancet Infectious Diseases
JF - The Lancet Infectious Diseases
ER -