European guidelines on the clinical management of HIV-1 tropism testing

Andrea De Luca, Linos Vandekerckhove, Annemarie Wensing, Rolf Kaiser, Francoise Brun Vezinet, Bonaventura Clotet, Stephan Dressler, Federico Garcia, Anna Maria Geretti, Thomas Klimkait, Klaus Korn, Bernard Masquelier, Carlo Federico Perno, Jonathan Shapiro, Vincent Soriano, Anders Sonnerborg, Anne Meke Vandamme, Chris Verhofstede, Hauke Walter, Maurizio ZazziCharles Boucher, Management Of Tropism Testing European Consensus Group

Risultato della ricerca: Contributo in rivistaArticolo in rivista

203 Citazioni (Scopus)

Abstract

Viral tropism is the ability of viruses to enter and infect specifi c host cells and is based on the ability of viruses to bind to receptors on those cells. Testing for HIV tropism is recommended before prescribing a chemokine receptor blocker. In most European countries, HIV tropism is identifi ed with tropism phenotype testing. New data support genotype analysis of the HIV third hypervariable loop (V3) for the identifi cation of tropism. The European Consensus Group on clinical management of tropism testing was established to make recommendations to clinicians and clinical virologists. The panel recommends HIV-tropism testing for the following groups: drug-naive patients in whom toxic eff ects are anticipated or for whom few treatment options are available; patients who have poor tolerability to or toxic eff ects from current treatment or who have CNS pathology; and patients for whom therapy has failed and a change in treatment is considered. In general, an enhanced sensitivity Trofi le assay and V3 population genotyping are the recommended methods. Genotypic methods are anticipated to be used more frequently in the clinical setting because of their greater accessibility, lower cost, and faster turnaround time than other methods. For the interpretation of V3 loop genotyping, clinically validated systems should be used when possible. Laboratories doing HIV tropism tests should have adequate quality assurance measures. Similarly, close collaboration between HIV clinicians and virologists is needed to ensure adequate diagnostic and treatment decisions.
Lingua originaleEnglish
pagine (da-a)394-407
Numero di pagine14
RivistaThe Lancet Infectious Diseases
Volume11
Stato di pubblicazionePubblicato - 2011

Keywords

  • tropism testing

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