European evidence-based guidelines on pancreatic cystic neoplasms

Marco Del Chiaro; Marc G. Besselink; Lianne Scholten; Marco J. Bruno; Djuna L. Cahen; Thomas M. Gress; Jeanin E. Van Hooft; Markus M. Lerch; Julia Mayerle; Thilo Hackert; Sohei Satoi; Alessandro Zerbi; David Cunningham; Claudio De Angelis; Marc Giovannini; Massimo Giovannini; Enrique De-Madaria; Peter Hegyi; Jonas Rosendahl; Helmut Friess; Riccardo Manfredi; Philippe Lévy; Francisco X. Real; Alain Sauvanet; Mohammed Abu Hilal; Giovanni Marchegiani; Irene Esposito; Paula Ghaneh; Marc R.W. Engelbrecht; Paul Fockens; Nadine C.M. Van Huijgevoort; Christopher Wolfgang; Claudio Bassi; Natalya B. Gubergrits; Caroline Verbeke; Günter Klöppel; Aldo Scarpa; Giuseppe Zamboni; Anne Marie Lennon; Malin Sund; Nikolaos Kartalis; Lars Grenacher; Massimo Falconi; Urban Arnelo; Kostantin V. Kopchak; Kofi Oppong; Colin Mckay; Truls Hauge; Kevin Conlon; Mustapha Adham; Güralp O. Ceyhan; Roberto Salvia; Christos Dervenis; Peter Allen; François Paye; Detlef K. Bartsch; Matthias Löhr; Massimiliano Mutignani; Johanna Laukkarinen; Richard Schulick; Roberto Valente; Thomas Seufferlein; Gabriele Capurso; Ajith Siriwardena; John P. Neoptolemos; Aldis Pukitis; Ralf Segersvärd; A. Aghdassi; S. Andrianello; P. Bossuyt; R. Bülow; K. Cárdenas-Jaén; P. Cortegoso; M. Fontana; Tecla Maria Fontana; L. Haeberle; M. Heckler; Andrey Litvin; K. Mann; C. Michalski; P. Michl; G. Nappo; G. Perri; Gianluigi Perri; S. Persson; F. Scheufele; F. Sclafani; M. Schmidt; L. Venezia; F. Volker; M. P. Vullierm; L. Wüsten

doi:10.1136/gutjnl-2018-316027

European evidence-based guidelines on pancreatic cystic neoplasms

Marco Del Chiaro, Marc G. Besselink, Lianne Scholten, Marco J. Bruno, Djuna L. Cahen, Thomas M. Gress, Jeanin E. Van Hooft, Markus M. Lerch, Julia Mayerle, Thilo Hackert, Sohei Satoi, Alessandro Zerbi, David Cunningham, Claudio De Angelis, Marc Giovannini, Massimo Giovannini, Enrique De-Madaria, Peter Hegyi, Jonas Rosendahl, Helmut FriessRiccardo Manfredi, Philippe Lévy, Francisco X. Real, Alain Sauvanet, Mohammed Abu Hilal, Giovanni Marchegiani, Irene Esposito, Paula Ghaneh, Marc R.W. Engelbrecht, Paul Fockens, Nadine C.M. Van Huijgevoort, Christopher Wolfgang, Claudio Bassi, Natalya B. Gubergrits, Caroline Verbeke, Günter Klöppel, Aldo Scarpa, Giuseppe Zamboni, Anne Marie Lennon, Malin Sund, Nikolaos Kartalis, Lars Grenacher, Massimo Falconi, Urban Arnelo, Kostantin V. Kopchak, Kofi Oppong, Colin Mckay, Truls Hauge, Kevin Conlon, Mustapha Adham, Güralp O. Ceyhan, Roberto Salvia, Christos Dervenis, Peter Allen, François Paye, Detlef K. Bartsch, Matthias Löhr, Massimiliano Mutignani, Johanna Laukkarinen, Richard Schulick, Roberto Valente, Thomas Seufferlein, Gabriele Capurso, Ajith Siriwardena, John P. Neoptolemos, Aldis Pukitis, Ralf Segersvärd, A. Aghdassi, S. Andrianello, P. Bossuyt, R. Bülow, K. Cárdenas-Jaén, P. Cortegoso, M. Fontana, Tecla Maria Fontana, L. Haeberle, M. Heckler, Andrey Litvin, K. Mann, C. Michalski, P. Michl, G. Nappo, G. Perri, Gianluigi Perri, S. Persson, F. Scheufele, F. Sclafani, M. Schmidt, L. Venezia, F. Volker, M. P. Vullierm, L. Wüsten

Risultato della ricerca: Contributo in rivista › Articolo in rivista

304 Citazioni (SciVal)

Abstract

Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. This guideline is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, European Pancreatic Club, European-African Hepato-Pancreato-Biliary Association, European Digestive Surgery, and the European Society of Gastrointestinal Endoscopy. It replaces the 2013 European consensus statement guidelines on PCN. European and non-European experts performed systematic reviews and used GRADE methodology to answer relevant clinical questions on nine topics (biomarkers, radiology, endoscopy, intraductal papillary mucinous neoplasm (IPMN), mucinous cystic neoplasm (MCN), serous cystic neoplasm, rare cysts, (neo)adjuvant treatment, and pathology). Recommendations include conservative management, relative and absolute indications for surgery. A conservative approach is recommended for asymptomatic MCN and IPMN measuring <40 mm without an enhancing nodule. Relative indications for surgery in IPMN include a main pancreatic duct (MPD) diameter between 5 and 9.9 mm or a cyst diameter ≥40 mm. Absolute indications for surgery in IPMN, due to the high-risk of malignant transformation, include jaundice, an enhancing mural nodule >5 mm, and MPD diameter >10 mm. Lifelong follow-up of IPMN is recommended in patients who are fit for surgery. The European evidence-based guidelines on PCN aim to improve the diagnosis and management of PCN.

Lingua originale	English
pagine (da-a)	789-804
Numero di pagine	16
Rivista	Gut
Volume	67
DOI	https://doi.org/10.1136/gutjnl-2018-316027
Stato di pubblicazione	Pubblicato - 2018

Keywords

Europe
Evidence-Based Practice
Humans
Pancreas
Pancreatic Cyst
Pancreatic Neoplasms
Practice Guidelines as Topic

Accesso al documento

10.1136/gutjnl-2018-316027

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Del Chiaro, M., Besselink, M. G., Scholten, L., Bruno, M. J., Cahen, D. L., Gress, T. M., Van Hooft, J. E., Lerch, M. M., Mayerle, J., Hackert, T., Satoi, S., Zerbi, A., Cunningham, D., De Angelis, C., Giovannini, M., Giovannini, M., De-Madaria, E., Hegyi, P., Rosendahl, J., ... Wüsten, L. (2018). European evidence-based guidelines on pancreatic cystic neoplasms. Gut, 67, 789-804. https://doi.org/10.1136/gutjnl-2018-316027

@article{388100a9cc97471290dbbd0c66194b93,

title = "European evidence-based guidelines on pancreatic cystic neoplasms",

abstract = "Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. This guideline is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, European Pancreatic Club, European-African Hepato-Pancreato-Biliary Association, European Digestive Surgery, and the European Society of Gastrointestinal Endoscopy. It replaces the 2013 European consensus statement guidelines on PCN. European and non-European experts performed systematic reviews and used GRADE methodology to answer relevant clinical questions on nine topics (biomarkers, radiology, endoscopy, intraductal papillary mucinous neoplasm (IPMN), mucinous cystic neoplasm (MCN), serous cystic neoplasm, rare cysts, (neo)adjuvant treatment, and pathology). Recommendations include conservative management, relative and absolute indications for surgery. A conservative approach is recommended for asymptomatic MCN and IPMN measuring <40 mm without an enhancing nodule. Relative indications for surgery in IPMN include a main pancreatic duct (MPD) diameter between 5 and 9.9 mm or a cyst diameter ≥40 mm. Absolute indications for surgery in IPMN, due to the high-risk of malignant transformation, include jaundice, an enhancing mural nodule >5 mm, and MPD diameter >10 mm. Lifelong follow-up of IPMN is recommended in patients who are fit for surgery. The European evidence-based guidelines on PCN aim to improve the diagnosis and management of PCN.",

keywords = "Europe, Evidence-Based Practice, Humans, Pancreas, Pancreatic Cyst, Pancreatic Neoplasms, Practice Guidelines as Topic, Europe, Evidence-Based Practice, Humans, Pancreas, Pancreatic Cyst, Pancreatic Neoplasms, Practice Guidelines as Topic",

author = "{Del Chiaro}, Marco and Besselink, {Marc G.} and Lianne Scholten and Bruno, {Marco J.} and Cahen, {Djuna L.} and Gress, {Thomas M.} and {Van Hooft}, {Jeanin E.} and Lerch, {Markus M.} and Julia Mayerle and Thilo Hackert and Sohei Satoi and Alessandro Zerbi and David Cunningham and {De Angelis}, Claudio and Marc Giovannini and Massimo Giovannini and Enrique De-Madaria and Peter Hegyi and Jonas Rosendahl and Helmut Friess and Riccardo Manfredi and Philippe L{\'e}vy and Real, {Francisco X.} and Alain Sauvanet and Hilal, {Mohammed Abu} and Giovanni Marchegiani and Irene Esposito and Paula Ghaneh and Engelbrecht, {Marc R.W.} and Paul Fockens and {Van Huijgevoort}, {Nadine C.M.} and Christopher Wolfgang and Claudio Bassi and Gubergrits, {Natalya B.} and Caroline Verbeke and G{\"u}nter Kl{\"o}ppel and Aldo Scarpa and Giuseppe Zamboni and Lennon, {Anne Marie} and Malin Sund and Nikolaos Kartalis and Lars Grenacher and Massimo Falconi and Urban Arnelo and Kopchak, {Kostantin V.} and Kofi Oppong and Colin Mckay and Truls Hauge and Kevin Conlon and Mustapha Adham and Ceyhan, {G{\"u}ralp O.} and Roberto Salvia and Christos Dervenis and Peter Allen and Fran{\c c}ois Paye and Bartsch, {Detlef K.} and Matthias L{\"o}hr and Massimiliano Mutignani and Johanna Laukkarinen and Richard Schulick and Roberto Valente and Thomas Seufferlein and Gabriele Capurso and Ajith Siriwardena and Neoptolemos, {John P.} and Aldis Pukitis and Ralf Segersv{\"a}rd and A. Aghdassi and S. Andrianello and P. Bossuyt and R. B{\"u}low and K. C{\'a}rdenas-Ja{\'e}n and P. Cortegoso and M. Fontana and Fontana, {Tecla Maria} and L. Haeberle and M. Heckler and Andrey Litvin and K. Mann and C. Michalski and P. Michl and G. Nappo and G. Perri and Gianluigi Perri and S. Persson and F. Scheufele and F. Sclafani and M. Schmidt and L. Venezia and F. Volker and Vullierm, {M. P.} and L. W{\"u}sten",

year = "2018",

doi = "10.1136/gutjnl-2018-316027",

language = "English",

volume = "67",

pages = "789--804",

journal = "Gut",

issn = "0017-5749",

publisher = "BMJ / British Medical Journal Publishing Group:PO Box 299, London WC1H 9TD United Kingdom:011 44 20 73836270, EMAIL: [email protected], INTERNET: http://www.bmjpg.com/bmj, Fax: 011 44 20 73836402",

}

Del Chiaro, M, Besselink, MG, Scholten, L, Bruno, MJ, Cahen, DL, Gress, TM, Van Hooft, JE, Lerch, MM, Mayerle, J, Hackert, T, Satoi, S, Zerbi, A, Cunningham, D, De Angelis, C, Giovannini, M, Giovannini, M, De-Madaria, E, Hegyi, P, Rosendahl, J, Friess, H, Manfredi, R, Lévy, P, Real, FX, Sauvanet, A, Hilal, MA, Marchegiani, G, Esposito, I, Ghaneh, P, Engelbrecht, MRW, Fockens, P, Van Huijgevoort, NCM, Wolfgang, C, Bassi, C, Gubergrits, NB, Verbeke, C, Klöppel, G, Scarpa, A, Zamboni, G, Lennon, AM, Sund, M, Kartalis, N, Grenacher, L, Falconi, M, Arnelo, U, Kopchak, KV, Oppong, K, Mckay, C, Hauge, T, Conlon, K, Adham, M, Ceyhan, GO, Salvia, R, Dervenis, C, Allen, P, Paye, F, Bartsch, DK, Löhr, M, Mutignani, M, Laukkarinen, J, Schulick, R, Valente, R, Seufferlein, T, Capurso, G, Siriwardena, A, Neoptolemos, JP, Pukitis, A, Segersvärd, R, Aghdassi, A, Andrianello, S, Bossuyt, P, Bülow, R, Cárdenas-Jaén, K, Cortegoso, P, Fontana, M, Fontana, TM, Haeberle, L, Heckler, M, Litvin, A, Mann, K, Michalski, C, Michl, P, Nappo, G, Perri, G, Perri, G, Persson, S, Scheufele, F, Sclafani, F, Schmidt, M, Venezia, L, Volker, F, Vullierm, MP & Wüsten, L 2018, 'European evidence-based guidelines on pancreatic cystic neoplasms', Gut, vol. 67, pagg. 789-804. https://doi.org/10.1136/gutjnl-2018-316027

TY - JOUR

T1 - European evidence-based guidelines on pancreatic cystic neoplasms

AU - Del Chiaro, Marco

AU - Besselink, Marc G.

AU - Scholten, Lianne

AU - Bruno, Marco J.

AU - Cahen, Djuna L.

AU - Gress, Thomas M.

AU - Van Hooft, Jeanin E.

AU - Lerch, Markus M.

AU - Mayerle, Julia

AU - Hackert, Thilo

AU - Satoi, Sohei

AU - Zerbi, Alessandro

AU - Cunningham, David

AU - De Angelis, Claudio

AU - Giovannini, Marc

AU - Giovannini, Massimo

AU - De-Madaria, Enrique

AU - Hegyi, Peter

AU - Rosendahl, Jonas

AU - Friess, Helmut

AU - Manfredi, Riccardo

AU - Lévy, Philippe

AU - Real, Francisco X.

AU - Sauvanet, Alain

AU - Hilal, Mohammed Abu

AU - Marchegiani, Giovanni

AU - Esposito, Irene

AU - Ghaneh, Paula

AU - Engelbrecht, Marc R.W.

AU - Fockens, Paul

AU - Van Huijgevoort, Nadine C.M.

AU - Wolfgang, Christopher

AU - Bassi, Claudio

AU - Gubergrits, Natalya B.

AU - Verbeke, Caroline

AU - Klöppel, Günter

AU - Scarpa, Aldo

AU - Zamboni, Giuseppe

AU - Lennon, Anne Marie

AU - Sund, Malin

AU - Kartalis, Nikolaos

AU - Grenacher, Lars

AU - Falconi, Massimo

AU - Arnelo, Urban

AU - Kopchak, Kostantin V.

AU - Oppong, Kofi

AU - Mckay, Colin

AU - Hauge, Truls

AU - Conlon, Kevin

AU - Adham, Mustapha

AU - Ceyhan, Güralp O.

AU - Salvia, Roberto

AU - Dervenis, Christos

AU - Allen, Peter

AU - Paye, François

AU - Bartsch, Detlef K.

AU - Löhr, Matthias

AU - Mutignani, Massimiliano

AU - Laukkarinen, Johanna

AU - Schulick, Richard

AU - Valente, Roberto

AU - Seufferlein, Thomas

AU - Capurso, Gabriele

AU - Siriwardena, Ajith

AU - Neoptolemos, John P.

AU - Pukitis, Aldis

AU - Segersvärd, Ralf

AU - Aghdassi, A.

AU - Andrianello, S.

AU - Bossuyt, P.

AU - Bülow, R.

AU - Cárdenas-Jaén, K.

AU - Cortegoso, P.

AU - Fontana, M.

AU - Fontana, Tecla Maria

AU - Haeberle, L.

AU - Heckler, M.

AU - Litvin, Andrey

AU - Mann, K.

AU - Michalski, C.

AU - Michl, P.

AU - Nappo, G.

AU - Perri, G.

AU - Perri, Gianluigi

AU - Persson, S.

AU - Scheufele, F.

AU - Sclafani, F.

AU - Schmidt, M.

AU - Venezia, L.

AU - Volker, F.

AU - Vullierm, M. P.

AU - Wüsten, L.

PY - 2018

Y1 - 2018

N2 - Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. This guideline is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, European Pancreatic Club, European-African Hepato-Pancreato-Biliary Association, European Digestive Surgery, and the European Society of Gastrointestinal Endoscopy. It replaces the 2013 European consensus statement guidelines on PCN. European and non-European experts performed systematic reviews and used GRADE methodology to answer relevant clinical questions on nine topics (biomarkers, radiology, endoscopy, intraductal papillary mucinous neoplasm (IPMN), mucinous cystic neoplasm (MCN), serous cystic neoplasm, rare cysts, (neo)adjuvant treatment, and pathology). Recommendations include conservative management, relative and absolute indications for surgery. A conservative approach is recommended for asymptomatic MCN and IPMN measuring <40 mm without an enhancing nodule. Relative indications for surgery in IPMN include a main pancreatic duct (MPD) diameter between 5 and 9.9 mm or a cyst diameter ≥40 mm. Absolute indications for surgery in IPMN, due to the high-risk of malignant transformation, include jaundice, an enhancing mural nodule >5 mm, and MPD diameter >10 mm. Lifelong follow-up of IPMN is recommended in patients who are fit for surgery. The European evidence-based guidelines on PCN aim to improve the diagnosis and management of PCN.

AB - Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. This guideline is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, European Pancreatic Club, European-African Hepato-Pancreato-Biliary Association, European Digestive Surgery, and the European Society of Gastrointestinal Endoscopy. It replaces the 2013 European consensus statement guidelines on PCN. European and non-European experts performed systematic reviews and used GRADE methodology to answer relevant clinical questions on nine topics (biomarkers, radiology, endoscopy, intraductal papillary mucinous neoplasm (IPMN), mucinous cystic neoplasm (MCN), serous cystic neoplasm, rare cysts, (neo)adjuvant treatment, and pathology). Recommendations include conservative management, relative and absolute indications for surgery. A conservative approach is recommended for asymptomatic MCN and IPMN measuring <40 mm without an enhancing nodule. Relative indications for surgery in IPMN include a main pancreatic duct (MPD) diameter between 5 and 9.9 mm or a cyst diameter ≥40 mm. Absolute indications for surgery in IPMN, due to the high-risk of malignant transformation, include jaundice, an enhancing mural nodule >5 mm, and MPD diameter >10 mm. Lifelong follow-up of IPMN is recommended in patients who are fit for surgery. The European evidence-based guidelines on PCN aim to improve the diagnosis and management of PCN.

KW - Europe

KW - Evidence-Based Practice

KW - Humans

KW - Pancreas

KW - Pancreatic Cyst

KW - Pancreatic Neoplasms

KW - Practice Guidelines as Topic

KW - Europe

KW - Evidence-Based Practice

KW - Humans

KW - Pancreas

KW - Pancreatic Cyst

KW - Pancreatic Neoplasms

KW - Practice Guidelines as Topic

UR - http://hdl.handle.net/10807/170464

U2 - 10.1136/gutjnl-2018-316027

DO - 10.1136/gutjnl-2018-316027

M3 - Article

SN - 0017-5749

VL - 67

SP - 789

EP - 804

JO - Gut

JF - Gut

ER -

European evidence-based guidelines on pancreatic cystic neoplasms

Abstract

Keywords

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