TY - JOUR
T1 - Estrogens as Antioxidant Modulators in Human Fertility
AU - Mancini, Antonio
AU - Raimondo, Sebastiano
AU - Persano, M
AU - Di Segni, C
AU - Cammarano, M
AU - Gadotti, G
AU - Silvestrini, Andrea
AU - Pontecorvi, Alfredo
AU - Meucci, Elisabetta
PY - 2013
Y1 - 2013
N2 - Among treatments proposed for idiopathic male infertility, antiestrogens, like tamoxifen, play a possible role. On the other hand, oxidative stress is a mechanism well recognized for deleterious effects on spermatozoa function. After reviewing the literature on the effects of estrogens in modulation of antioxidant systems, in both sexes, and in different in vivo and in vitro models, we suggest, also on the basis of personal data, that a tamoxifen treatment could be active via an increase in seminal antioxidants.
AB - Among treatments proposed for idiopathic male infertility, antiestrogens, like tamoxifen, play a possible role. On the other hand, oxidative stress is a mechanism well recognized for deleterious effects on spermatozoa function. After reviewing the literature on the effects of estrogens in modulation of antioxidant systems, in both sexes, and in different in vivo and in vitro models, we suggest, also on the basis of personal data, that a tamoxifen treatment could be active via an increase in seminal antioxidants.
KW - antioxidant
KW - antioxidant
UR - https://publicatt.unicatt.it/handle/10807/52812
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84890090357&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84890090357&origin=inward
U2 - 10.1155/2013/607939
DO - 10.1155/2013/607939
M3 - Article
SN - 1687-8337
VL - 2013
SP - 607939
EP - 607939
JO - International Journal of Endocrinology
JF - International Journal of Endocrinology
IS - Novembre
ER -