Estradiol protective role in atherogenesis through LDL structure modification

Massimiliano Papi, Gabriele Ciasca, Giuseppe Maulucci, Marco De Spirito, Alessandro Maiorana, Valentina Palmieri, Roberto Brunelli, Tiziana Parasassi

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

1 Citazioni (Scopus)

Abstract

Relevant physiological functions are exerted by circulating low density lipoprotein (LDL) as well as eventual pathological processes triggering atherogenesis. Modulation of these functions can well be founded on modifications of LDL structure. Given its large dimension, multicomponent organization and strong interactions between the protein apoB-100 and lipids, determining LDL 3D structure remains a challenge. We propose a novel quantitative physical approach to this complex biological problem. We introduce a three-component model, fitted to small angle x-ray scattering data on LDL maintained in physiological conditions, able to achieve a consistent 3D structure. Unexpected features include three distinct protein domains protruding out of a sphere, quite rough in its surface, where several core lipid areas are exposed. All LDL components are affected by 17-β-estradiol (E2) binding to apoB-100. Mostly one of the three protruding protein domains, dramatically reducing its presence on the surface and with a consequent increase of core lipids' exposure. This result suggests a structural basis for some E2 protecting roles and LDL physiological modifications.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaJOURNAL OF PHYSICS D. APPLIED PHYSICS
Volume49
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • 17-β-estradiol
  • Acoustics and Ultrasonics
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • apoB-100
  • atherosclerosis
  • low density lipoprotein
  • small angle x-ray scattering

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