Estimation of lead-time bias and its impact on the outcome of surveillance for the early diagnosis of hepatocellular carcinoma

Gian Ludovico Rapaccini; Antonio Gasbarrini; Alessandro Cucchetti; Franco Trevisani; Anna Pecorelli; Virginia Erroi; Fabio Farinati; Francesca Ciccarese; Mariella Di Marco; Eugenio Caturelli; Edoardo G. Giannini; Marco Zoli; Franco Borzio; Giuseppe Cabibbo; Martina Felder; Rodolfo Sacco; Francesco Giuseppe Foschi; Gabriele Missale; Filomena Morisco; Gianluca Svegliati Baroni; Roberto Virdone; Mauro Bernardi; Antonio D. Pinna

doi:10.1016/j.jhep.2014.03.037

Estimation of lead-time bias and its impact on the outcome of surveillance for the early diagnosis of hepatocellular carcinoma

Gian Ludovico Rapaccini, Antonio Gasbarrini, Alessandro Cucchetti, Franco Trevisani, Anna Pecorelli, Virginia Erroi, Fabio Farinati, Francesca Ciccarese, Mariella Di Marco, Eugenio Caturelli, Edoardo G. Giannini, Marco Zoli, Franco Borzio, Giuseppe Cabibbo, Martina Felder, Rodolfo Sacco, Francesco Giuseppe Foschi, Gabriele Missale, Filomena Morisco, Gianluca Svegliati BaroniRoberto Virdone, Mauro Bernardi, Antonio D. Pinna

Risultato della ricerca: Contributo in rivista › Articolo in rivista

63 Citazioni (Scopus)

Abstract

Lead-time is the time by which diagnosis is anticipated by screening/surveillance with respect to the symptomatic detection of a disease. Any screening program, including surveillance for hepatocellular carcinoma (HCC), is subject to lead-time bias. Data regarding lead-time for HCC are lacking. Aims of the present study were to calculate lead-time and to assess its impact on the benefit obtainable from the surveillance of cirrhotic patients.

Lingua originale	English
pagine (da-a)	333-341
Numero di pagine	9
Rivista	Journal of Hepatology
Volume	61
DOI	https://doi.org/10.1016/j.jhep.2014.03.037
Stato di pubblicazione	Pubblicato - 2014

Keywords

Cirrhosis
Hepatocellular carcinoma
Lead-time bias
Surveillance

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10.1016/j.jhep.2014.03.037

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Rapaccini, G. L., Gasbarrini, A., Cucchetti, A., Trevisani, F., Pecorelli, A., Erroi, V., Farinati, F., Ciccarese, F., Di Marco, M., Caturelli, E., Giannini, E. G., Zoli, M., Borzio, F., Cabibbo, G., Felder, M., Sacco, R., Foschi, F. G., Missale, G., Morisco, F., ... Pinna, A. D. (2014). Estimation of lead-time bias and its impact on the outcome of surveillance for the early diagnosis of hepatocellular carcinoma. Journal of Hepatology, 61, 333-341. https://doi.org/10.1016/j.jhep.2014.03.037

Rapaccini, Gian Ludovico ; Gasbarrini, Antonio ; Cucchetti, Alessandro ; Trevisani, Franco ; Pecorelli, Anna ; Erroi, Virginia ; Farinati, Fabio ; Ciccarese, Francesca ; Di Marco, Mariella ; Caturelli, Eugenio ; Giannini, Edoardo G. ; Zoli, Marco ; Borzio, Franco ; Cabibbo, Giuseppe ; Felder, Martina ; Sacco, Rodolfo ; Foschi, Francesco Giuseppe ; Missale, Gabriele ; Morisco, Filomena ; Baroni, Gianluca Svegliati ; Virdone, Roberto ; Bernardi, Mauro ; Pinna, Antonio D. / Estimation of lead-time bias and its impact on the outcome of surveillance for the early diagnosis of hepatocellular carcinoma. In: Journal of Hepatology. 2014 ; Vol. 61. pagg. 333-341.

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title = "Estimation of lead-time bias and its impact on the outcome of surveillance for the early diagnosis of hepatocellular carcinoma",

abstract = "Lead-time is the time by which diagnosis is anticipated by screening/surveillance with respect to the symptomatic detection of a disease. Any screening program, including surveillance for hepatocellular carcinoma (HCC), is subject to lead-time bias. Data regarding lead-time for HCC are lacking. Aims of the present study were to calculate lead-time and to assess its impact on the benefit obtainable from the surveillance of cirrhotic patients.",

keywords = "Cirrhosis, Hepatocellular carcinoma, Lead-time bias, Surveillance, Cirrhosis, Hepatocellular carcinoma, Lead-time bias, Surveillance",

author = "Rapaccini, {Gian Ludovico} and Antonio Gasbarrini and Alessandro Cucchetti and Franco Trevisani and Anna Pecorelli and Virginia Erroi and Fabio Farinati and Francesca Ciccarese and {Di Marco}, Mariella and Eugenio Caturelli and Giannini, {Edoardo G.} and Marco Zoli and Franco Borzio and Giuseppe Cabibbo and Martina Felder and Rodolfo Sacco and Foschi, {Francesco Giuseppe} and Gabriele Missale and Filomena Morisco and Baroni, {Gianluca Svegliati} and Roberto Virdone and Mauro Bernardi and Pinna, {Antonio D.}",

year = "2014",

doi = "10.1016/j.jhep.2014.03.037",

language = "English",

volume = "61",

pages = "333--341",

journal = "Journal of Hepatology",

issn = "0168-8278",

publisher = "Blackwell Munksgaard:PO Box 2148, Periodicals Department, DK-1016 Copenhagen K Denmark:011 45 33 755913, EMAIL: agentservices@oxon.blackwellpublishing.com, INTERNET: http://www.blackwellmunksgaard.com, Fax: 011 45 77 333377",

}

Rapaccini, GL, Gasbarrini, A, Cucchetti, A, Trevisani, F, Pecorelli, A, Erroi, V, Farinati, F, Ciccarese, F, Di Marco, M, Caturelli, E, Giannini, EG, Zoli, M, Borzio, F, Cabibbo, G, Felder, M, Sacco, R, Foschi, FG, Missale, G, Morisco, F, Baroni, GS, Virdone, R, Bernardi, M & Pinna, AD 2014, 'Estimation of lead-time bias and its impact on the outcome of surveillance for the early diagnosis of hepatocellular carcinoma', Journal of Hepatology, vol. 61, pagg. 333-341. https://doi.org/10.1016/j.jhep.2014.03.037

Estimation of lead-time bias and its impact on the outcome of surveillance for the early diagnosis of hepatocellular carcinoma. / Rapaccini, Gian Ludovico; Gasbarrini, Antonio; Cucchetti, Alessandro; Trevisani, Franco; Pecorelli, Anna; Erroi, Virginia; Farinati, Fabio; Ciccarese, Francesca; Di Marco, Mariella; Caturelli, Eugenio; Giannini, Edoardo G.; Zoli, Marco; Borzio, Franco; Cabibbo, Giuseppe; Felder, Martina; Sacco, Rodolfo; Foschi, Francesco Giuseppe; Missale, Gabriele; Morisco, Filomena; Baroni, Gianluca Svegliati; Virdone, Roberto; Bernardi, Mauro; Pinna, Antonio D.

In: Journal of Hepatology, Vol. 61, 2014, pag. 333-341.

Risultato della ricerca: Contributo in rivista › Articolo in rivista

TY - JOUR

T1 - Estimation of lead-time bias and its impact on the outcome of surveillance for the early diagnosis of hepatocellular carcinoma

AU - Rapaccini, Gian Ludovico

AU - Gasbarrini, Antonio

AU - Cucchetti, Alessandro

AU - Trevisani, Franco

AU - Pecorelli, Anna

AU - Erroi, Virginia

AU - Farinati, Fabio

AU - Ciccarese, Francesca

AU - Di Marco, Mariella

AU - Caturelli, Eugenio

AU - Giannini, Edoardo G.

AU - Zoli, Marco

AU - Borzio, Franco

AU - Cabibbo, Giuseppe

AU - Felder, Martina

AU - Sacco, Rodolfo

AU - Foschi, Francesco Giuseppe

AU - Missale, Gabriele

AU - Morisco, Filomena

AU - Baroni, Gianluca Svegliati

AU - Virdone, Roberto

AU - Bernardi, Mauro

AU - Pinna, Antonio D.

PY - 2014

Y1 - 2014

N2 - Lead-time is the time by which diagnosis is anticipated by screening/surveillance with respect to the symptomatic detection of a disease. Any screening program, including surveillance for hepatocellular carcinoma (HCC), is subject to lead-time bias. Data regarding lead-time for HCC are lacking. Aims of the present study were to calculate lead-time and to assess its impact on the benefit obtainable from the surveillance of cirrhotic patients.

AB - Lead-time is the time by which diagnosis is anticipated by screening/surveillance with respect to the symptomatic detection of a disease. Any screening program, including surveillance for hepatocellular carcinoma (HCC), is subject to lead-time bias. Data regarding lead-time for HCC are lacking. Aims of the present study were to calculate lead-time and to assess its impact on the benefit obtainable from the surveillance of cirrhotic patients.

KW - Cirrhosis

KW - Hepatocellular carcinoma

KW - Lead-time bias

KW - Surveillance

KW - Cirrhosis

KW - Hepatocellular carcinoma

KW - Lead-time bias

KW - Surveillance

UR - http://hdl.handle.net/10807/60760

U2 - 10.1016/j.jhep.2014.03.037

DO - 10.1016/j.jhep.2014.03.037

M3 - Article

VL - 61

SP - 333

EP - 341

JO - Journal of Hepatology

JF - Journal of Hepatology

SN - 0168-8278

ER -

Estimation of lead-time bias and its impact on the outcome of surveillance for the early diagnosis of hepatocellular carcinoma

Abstract

Keywords

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