Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival

Ac Piscaglia; Td Shupe; Giovambattista Pani; Valentina Tesori; Antonio Gasbarrini; Be Petersen

doi:10.1016/j.jhep.2009.02.022

Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival

Ac Piscaglia, Td Shupe, Giovambattista Pani, Valentina Tesori, Antonio Gasbarrini, Be Petersen

Risultato della ricerca: Contributo in rivista › Articolo in rivista

14 Citazioni (Scopus)

Abstract

Oval cells (OCs), putative hepatic stem cells, may give rise to liver cancers. We developed a carcinogenesis regimen, based upon induction of OC proliferation prior to carcinogen exposure. In our model, rats subjected to 2-acetylaminofluorene/ partial-hepatectomy followed by aflatoxin injection (APA regimen) developed well-differentiated hepatocholangiocarcinomas. The aim of this study was to establish and characterize cancer cell lines from this animal model.

Lingua originale	English
pagine (da-a)	77-92
Numero di pagine	16
Rivista	Journal of Hepatology
Volume	51
DOI	https://doi.org/10.1016/j.jhep.2009.02.022
Stato di pubblicazione	Pubblicato - 2009

Keywords

2-Acetylaminofluorene
Aflatoxin B1
Animals
Carcinoma, Hepatocellular
Cell Line, Tumor
Cell Movement
Cell Proliferation
Cell Survival
Cholangiocarcinoma
Granulocyte Colony-Stimulating Factor
Hepatectomy
Hepatocyte Growth Factor
Liver Neoplasms
Male
Neoplasm Metastasis
Proto-Oncogene Proteins c-met
Rats
Rats, Inbred F344
Receptors, Granulocyte Colony-Stimulating Factor

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10.1016/j.jhep.2009.02.022

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title = "Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival",

abstract = "Oval cells (OCs), putative hepatic stem cells, may give rise to liver cancers. We developed a carcinogenesis regimen, based upon induction of OC proliferation prior to carcinogen exposure. In our model, rats subjected to 2-acetylaminofluorene/ partial-hepatectomy followed by aflatoxin injection (APA regimen) developed well-differentiated hepatocholangiocarcinomas. The aim of this study was to establish and characterize cancer cell lines from this animal model.",

keywords = "2-Acetylaminofluorene, Aflatoxin B1, Animals, Carcinoma, Hepatocellular, Cell Line, Tumor, Cell Movement, Cell Proliferation, Cell Survival, Cholangiocarcinoma, Granulocyte Colony-Stimulating Factor, Hepatectomy, Hepatocyte Growth Factor, Liver Neoplasms, Male, Neoplasm Metastasis, Proto-Oncogene Proteins c-met, Rats, Rats, Inbred F344, Receptors, Granulocyte Colony-Stimulating Factor, 2-Acetylaminofluorene, Aflatoxin B1, Animals, Carcinoma, Hepatocellular, Cell Line, Tumor, Cell Movement, Cell Proliferation, Cell Survival, Cholangiocarcinoma, Granulocyte Colony-Stimulating Factor, Hepatectomy, Hepatocyte Growth Factor, Liver Neoplasms, Male, Neoplasm Metastasis, Proto-Oncogene Proteins c-met, Rats, Rats, Inbred F344, Receptors, Granulocyte Colony-Stimulating Factor",

author = "Ac Piscaglia and Td Shupe and Giovambattista Pani and Valentina Tesori and Antonio Gasbarrini and Be Petersen",

year = "2009",

doi = "10.1016/j.jhep.2009.02.022",

language = "English",

volume = "51",

pages = "77--92",

journal = "Journal of Hepatology",

issn = "0168-8278",

publisher = "Blackwell Munksgaard:PO Box 2148, Periodicals Department, DK-1016 Copenhagen K Denmark:011 45 33 755913, EMAIL: agentservices@oxon.blackwellpublishing.com, INTERNET: http://www.blackwellmunksgaard.com, Fax: 011 45 77 333377",

}

Piscaglia, A, Shupe, T, Pani, G, Tesori, V, Gasbarrini, A & Petersen, B 2009, 'Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival', Journal of Hepatology, vol. 51, pagg. 77-92. https://doi.org/10.1016/j.jhep.2009.02.022

Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival. / Piscaglia, Ac; Shupe, Td; Pani, Giovambattista et al.

In: Journal of Hepatology, Vol. 51, 2009, pag. 77-92.

Risultato della ricerca: Contributo in rivista › Articolo in rivista

TY - JOUR

T1 - Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival

AU - Piscaglia, Ac

AU - Shupe, Td

AU - Pani, Giovambattista

AU - Tesori, Valentina

AU - Gasbarrini, Antonio

AU - Petersen, Be

PY - 2009

Y1 - 2009

N2 - Oval cells (OCs), putative hepatic stem cells, may give rise to liver cancers. We developed a carcinogenesis regimen, based upon induction of OC proliferation prior to carcinogen exposure. In our model, rats subjected to 2-acetylaminofluorene/ partial-hepatectomy followed by aflatoxin injection (APA regimen) developed well-differentiated hepatocholangiocarcinomas. The aim of this study was to establish and characterize cancer cell lines from this animal model.

AB - Oval cells (OCs), putative hepatic stem cells, may give rise to liver cancers. We developed a carcinogenesis regimen, based upon induction of OC proliferation prior to carcinogen exposure. In our model, rats subjected to 2-acetylaminofluorene/ partial-hepatectomy followed by aflatoxin injection (APA regimen) developed well-differentiated hepatocholangiocarcinomas. The aim of this study was to establish and characterize cancer cell lines from this animal model.

KW - 2-Acetylaminofluorene

KW - Aflatoxin B1

KW - Animals

KW - Carcinoma, Hepatocellular

KW - Cell Line, Tumor

KW - Cell Movement

KW - Cell Proliferation

KW - Cell Survival

KW - Cholangiocarcinoma

KW - Granulocyte Colony-Stimulating Factor

KW - Hepatectomy

KW - Hepatocyte Growth Factor

KW - Liver Neoplasms

KW - Male

KW - Neoplasm Metastasis

KW - Proto-Oncogene Proteins c-met

KW - Rats

KW - Rats, Inbred F344

KW - Receptors, Granulocyte Colony-Stimulating Factor

KW - 2-Acetylaminofluorene

KW - Aflatoxin B1

KW - Animals

KW - Carcinoma, Hepatocellular

KW - Cell Line, Tumor

KW - Cell Movement

KW - Cell Proliferation

KW - Cell Survival

KW - Cholangiocarcinoma

KW - Granulocyte Colony-Stimulating Factor

KW - Hepatectomy

KW - Hepatocyte Growth Factor

KW - Liver Neoplasms

KW - Male

KW - Neoplasm Metastasis

KW - Proto-Oncogene Proteins c-met

KW - Rats

KW - Rats, Inbred F344

KW - Receptors, Granulocyte Colony-Stimulating Factor

UR - http://hdl.handle.net/10807/21702

U2 - 10.1016/j.jhep.2009.02.022

DO - 10.1016/j.jhep.2009.02.022

M3 - Article

SN - 0168-8278

VL - 51

SP - 77

EP - 92

JO - Journal of Hepatology

JF - Journal of Hepatology

ER -

Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival

Abstract

Keywords

OSS delle Nazioni Unite

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