@article{87922a214c6b4c1f949b7ff7783614c3,
title = "Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival",
abstract = "Oval cells (OCs), putative hepatic stem cells, may give rise to liver cancers. We developed a carcinogenesis regimen, based upon induction of OC proliferation prior to carcinogen exposure. In our model, rats subjected to 2-acetylaminofluorene/ partial-hepatectomy followed by aflatoxin injection (APA regimen) developed well-differentiated hepatocholangiocarcinomas. The aim of this study was to establish and characterize cancer cell lines from this animal model.",
keywords = "2-Acetylaminofluorene, Aflatoxin B1, Animals, Carcinoma, Hepatocellular, Cell Line, Tumor, Cell Movement, Cell Proliferation, Cell Survival, Cholangiocarcinoma, Granulocyte Colony-Stimulating Factor, Hepatectomy, Hepatocyte Growth Factor, Liver Neoplasms, Male, Neoplasm Metastasis, Proto-Oncogene Proteins c-met, Rats, Rats, Inbred F344, Receptors, Granulocyte Colony-Stimulating Factor, 2-Acetylaminofluorene, Aflatoxin B1, Animals, Carcinoma, Hepatocellular, Cell Line, Tumor, Cell Movement, Cell Proliferation, Cell Survival, Cholangiocarcinoma, Granulocyte Colony-Stimulating Factor, Hepatectomy, Hepatocyte Growth Factor, Liver Neoplasms, Male, Neoplasm Metastasis, Proto-Oncogene Proteins c-met, Rats, Rats, Inbred F344, Receptors, Granulocyte Colony-Stimulating Factor",
author = "Giovambattista Pani and Antonio Gasbarrini and Valentina Tesori and Ac Piscaglia and Td Shupe and Be Petersen",
year = "2009",
doi = "10.1016/j.jhep.2009.02.022",
language = "English",
volume = "51",
pages = "77--92",
journal = "Journal of Hepatology",
issn = "0168-8278",
publisher = "Blackwell Munksgaard:PO Box 2148, Periodicals Department, DK-1016 Copenhagen K Denmark:011 45 33 755913, EMAIL: agentservices@oxon.blackwellpublishing.com, INTERNET: http://www.blackwellmunksgaard.com, Fax: 011 45 77 333377",
}