Abstract
Oval cells (OCs), putative hepatic stem cells, may give rise to liver cancers. We developed a carcinogenesis regimen, based upon induction of OC proliferation prior to carcinogen exposure. In our model, rats subjected to 2-acetylaminofluorene/ partial-hepatectomy followed by aflatoxin injection (APA regimen) developed well-differentiated hepatocholangiocarcinomas. The aim of this study was to establish and characterize cancer cell lines from this animal model.
Lingua originale | Inglese |
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pagine (da-a) | 77-92 |
Numero di pagine | 16 |
Rivista | Journal of Hepatology |
Volume | 51 |
DOI | |
Stato di pubblicazione | Pubblicato - 2009 |
Keywords
- 2-Acetylaminofluorene
- Aflatoxin B1
- Animals
- Carcinoma, Hepatocellular
- Cell Line, Tumor
- Cell Movement
- Cell Proliferation
- Cell Survival
- Cholangiocarcinoma
- Granulocyte Colony-Stimulating Factor
- Hepatectomy
- Hepatocyte Growth Factor
- Liver Neoplasms
- Male
- Neoplasm Metastasis
- Proto-Oncogene Proteins c-met
- Rats
- Rats, Inbred F344
- Receptors, Granulocyte Colony-Stimulating Factor