Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival

Giovambattista Pani, Antonio Gasbarrini, Valentina Tesori, Ac Piscaglia, Td Shupe, Be Petersen

Risultato della ricerca: Contributo in rivistaArticolo in rivista

14 Citazioni (Scopus)

Abstract

Oval cells (OCs), putative hepatic stem cells, may give rise to liver cancers. We developed a carcinogenesis regimen, based upon induction of OC proliferation prior to carcinogen exposure. In our model, rats subjected to 2-acetylaminofluorene/ partial-hepatectomy followed by aflatoxin injection (APA regimen) developed well-differentiated hepatocholangiocarcinomas. The aim of this study was to establish and characterize cancer cell lines from this animal model.
Lingua originaleEnglish
pagine (da-a)77-92
Numero di pagine16
RivistaJournal of Hepatology
Volume51
DOI
Stato di pubblicazionePubblicato - 2009

Keywords

  • 2-Acetylaminofluorene
  • Aflatoxin B1
  • Animals
  • Carcinoma, Hepatocellular
  • Cell Line, Tumor
  • Cell Movement
  • Cell Proliferation
  • Cell Survival
  • Cholangiocarcinoma
  • Granulocyte Colony-Stimulating Factor
  • Hepatectomy
  • Hepatocyte Growth Factor
  • Liver Neoplasms
  • Male
  • Neoplasm Metastasis
  • Proto-Oncogene Proteins c-met
  • Rats
  • Rats, Inbred F344
  • Receptors, Granulocyte Colony-Stimulating Factor

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