Abstract
This meta-analysis was planned to define the role of erythropoiesis-stimulating agents (ESAs) in gynecological cancer patients, receiving myelosuppressive treatment.Pubmed, Medline and Scopus were searched to select English-language articles. Only randomized controlled trials (RCTs) were included. Endpoints were incidence of transfusions, thrombotic events (TE), deaths, and failures. Odd ratio (OR) with 95% confidence interval (CI) was calculated using fixed or random effects model.In seven RCTs ESAs studies of 892 patients under treatment, use of ESAs correlates with a significant reduction of transfusions rate (OR = 0.35; 95% CI: 0.19-0.65; p = 0.008). OR for overall mortality was 1.10 (95% CI 0.82-1.49; p = 0.53). ESAs OR for disease failure in 5 studies was 1.71 (95% CI: 0.90-3.24; p = 0.1).This meta-analysis, even if limited by few RCTs, suggests that ESAs reduce transfusions without increasing mortality or disease progression in gynecological cancer patients receiving treatment.
Lingua originale | English |
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pagine (da-a) | 123-128 |
Numero di pagine | 6 |
Rivista | CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY |
Volume | 99 |
DOI | |
Stato di pubblicazione | Pubblicato - 2016 |
Keywords
- Anemia
- Chemotherapy
- Erythropoiesis-stimulating agents
- Gynecological cancer
- Mortality
- Transfusion