Epithelial-mesenchymal transition:A new target in anticancer drug discovery

Ruggero De Maria Marchiano, Fabrizio Marcucci, Giorgio Stassi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

198 Citazioni (Scopus)

Abstract

The conversion of cells with an epithelial phenotype into cells with a mesenchymal phenotype, referred to as epithelial-mesenchymal transition, is a critical process for embryonic development that also occurs in adult life, particularly during tumour progression. Tumour cells undergoing epithelial-mesenchymal transition acquire the capacity to disarm the body's antitumour defences, resist apoptosis and anticancer drugs, disseminate throughout the organism, and act as a reservoir that replenishes and expands the tumour cell population. Epithelial-mesenchymal transition is therefore becoming a target of prime interest for anticancer therapy. Here, we discuss the screening and classification of compounds that affect epithelial-mesenchymal transition, highlight some compounds of particular interest, and address issues related to their clinical application.
Lingua originaleEnglish
pagine (da-a)311-325
Numero di pagine15
RivistaNature Reviews Drug Discovery
Volume15
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Adult
  • Antineoplastic Agents
  • Drug Discovery
  • Drug Discovery3003 Pharmaceutical Science
  • Epithelial-Mesenchymal Transition
  • Humans
  • Neoplasms
  • Pharmacology

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