TY - JOUR
T1 - Epileptic seizures as a manifestation of cow's milk allergy: A studied relationship and description of our pediatric experience
AU - Falsaperla, Raffaele
AU - Pavone, Piero
AU - Miceli Sopo, Stefano
AU - Mahmood, Fahad
AU - Scalia, Ferdinando
AU - Corsello, Giovanni
AU - Lubrano, Riccardo
AU - Vitaliti, Giovanna
PY - 2014
Y1 - 2014
N2 - Adverse reactions after ingestion of cow's milk proteins can occur at any age, from birth and even amongst exclusively breast-fed infants, although not all of these are hypersensitivity reactions. The most common presentations related to cow's milk protein allergy are skin reactions, failure to thrive, anaphylaxis as well as gastrointestinal and respiratory disorders. In addition, several cases of cow's milk protein allergy in the literature have documented neurological involvement, manifesting with convulsive seizures in children. This may be due to CNS spread of a peripheral inflammatory response. Furthermore, there is evidence that pro-inflammatory cytokines are responsible for disrupting the blood-brain barrier, causing focal CNS inflammation thereby triggering seizures, although further studies are needed to clarify the pathogenic relationship between atopy and its neurological manifestations. This review aims to analyze current published data on the link between cow's milk protein allergy and epileptic events, highlighting scientific evidence for any potential pathogenic mechanism and describing our clinical experience in pediatrics.
AB - Adverse reactions after ingestion of cow's milk proteins can occur at any age, from birth and even amongst exclusively breast-fed infants, although not all of these are hypersensitivity reactions. The most common presentations related to cow's milk protein allergy are skin reactions, failure to thrive, anaphylaxis as well as gastrointestinal and respiratory disorders. In addition, several cases of cow's milk protein allergy in the literature have documented neurological involvement, manifesting with convulsive seizures in children. This may be due to CNS spread of a peripheral inflammatory response. Furthermore, there is evidence that pro-inflammatory cytokines are responsible for disrupting the blood-brain barrier, causing focal CNS inflammation thereby triggering seizures, although further studies are needed to clarify the pathogenic relationship between atopy and its neurological manifestations. This review aims to analyze current published data on the link between cow's milk protein allergy and epileptic events, highlighting scientific evidence for any potential pathogenic mechanism and describing our clinical experience in pediatrics.
KW - Animals
KW - Atypical clinical features
KW - CNS inflammation
KW - Child
KW - Cow's milk allergy
KW - Humans
KW - Milk
KW - Milk Hypersensitivity
KW - Pro-inflammatory cytokines
KW - Seizures
KW - Animals
KW - Atypical clinical features
KW - CNS inflammation
KW - Child
KW - Cow's milk allergy
KW - Humans
KW - Milk
KW - Milk Hypersensitivity
KW - Pro-inflammatory cytokines
KW - Seizures
UR - http://hdl.handle.net/10807/167369
U2 - 10.1586/1744666X.2014.977259
DO - 10.1586/1744666X.2014.977259
M3 - Article
SN - 1744-666X
VL - 10
SP - 1597
EP - 1609
JO - Expert Review of Clinical Immunology
JF - Expert Review of Clinical Immunology
ER -