Epileptic seizures as a manifestation of cow's milk allergy: A studied relationship and description of our pediatric experience

Stefano Miceli Sopo, Raffaele Falsaperla, Piero Pavone, Fahad Mahmood, Ferdinando Scalia, Giovanni Corsello, Riccardo Lubrano, Giovanna Vitaliti

Risultato della ricerca: Contributo in rivistaArticolo in rivista

11 Citazioni (Scopus)

Abstract

Adverse reactions after ingestion of cow's milk proteins can occur at any age, from birth and even amongst exclusively breast-fed infants, although not all of these are hypersensitivity reactions. The most common presentations related to cow's milk protein allergy are skin reactions, failure to thrive, anaphylaxis as well as gastrointestinal and respiratory disorders. In addition, several cases of cow's milk protein allergy in the literature have documented neurological involvement, manifesting with convulsive seizures in children. This may be due to CNS spread of a peripheral inflammatory response. Furthermore, there is evidence that pro-inflammatory cytokines are responsible for disrupting the blood-brain barrier, causing focal CNS inflammation thereby triggering seizures, although further studies are needed to clarify the pathogenic relationship between atopy and its neurological manifestations. This review aims to analyze current published data on the link between cow's milk protein allergy and epileptic events, highlighting scientific evidence for any potential pathogenic mechanism and describing our clinical experience in pediatrics.
Lingua originaleEnglish
pagine (da-a)1597-1609
Numero di pagine13
RivistaExpert Review of Clinical Immunology
Volume10
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Atypical clinical features
  • CNS inflammation
  • Cow's milk allergy
  • Pro-inflammatory cytokines
  • Seizures
  • Child
  • Humans
  • Milk
  • Milk Hypersensitivity
  • Animals

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