Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior

Francesco Pierconti; Maurizio Martini; Francesco Pinto; Tonia Cenci; Sara Capodimonti; Alessandro Calarco; Pierfrancesco Bassi; Luigi Maria Larocca

doi:10.1002/pros.21245

Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior

Francesco Pierconti
, Maurizio Martini
, Francesco Pinto
, Tonia Cenci
, Sara Capodimonti
, Alessandro Calarco
, Pierfrancesco Bassi
, Luigi Maria Larocca

Risultato della ricerca: Contributo in rivista › Articolo

59 Citazioni (Scopus)

Abstract

Chronic inflammation and subsequent tissutal alterations may play a key role in prostate carcinogenesis. In this way, molecular alterations of the suppressor of cytokine signaling 3 (SOCS3), one of the most important inhibitory molecule of inflammatory signal transduction circuitries, could contribute to explain the pleiotropic role of interleukin-6 (IL-6) in this type of cancer.

Lingua originale	Inglese
pagine (da-a)	318-325
Numero di pagine	8
Rivista	THE PROSTATE
Volume	71
DOI	https://doi.org/10.1002/pros.21245
Stato di pubblicazione	Pubblicato - 2011

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Keywords

Aged
Base Sequence
DNA Methylation
Gene Silencing
Humans
Male
Middle Aged
Molecular Sequence Data
Promoter Regions, Genetic
Prostatic Hyperplasia
Prostatic Neoplasms
Suppressor of Cytokine Signaling Proteins

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10.1002/pros.21245

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title = "Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior",

abstract = "Chronic inflammation and subsequent tissutal alterations may play a key role in prostate carcinogenesis. In this way, molecular alterations of the suppressor of cytokine signaling 3 (SOCS3), one of the most important inhibitory molecule of inflammatory signal transduction circuitries, could contribute to explain the pleiotropic role of interleukin-6 (IL-6) in this type of cancer.",

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author = "Francesco Pierconti and Maurizio Martini and Francesco Pinto and Tonia Cenci and Sara Capodimonti and Alessandro Calarco and Pierfrancesco Bassi and Larocca, \{Luigi Maria\}",

year = "2011",

doi = "10.1002/pros.21245",

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TY - JOUR

T1 - Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior

AU - Pierconti, Francesco

AU - Martini, Maurizio

AU - Pinto, Francesco

AU - Cenci, Tonia

AU - Capodimonti, Sara

AU - Calarco, Alessandro

AU - Bassi, Pierfrancesco

AU - Larocca, Luigi Maria

PY - 2011

Y1 - 2011

N2 - Chronic inflammation and subsequent tissutal alterations may play a key role in prostate carcinogenesis. In this way, molecular alterations of the suppressor of cytokine signaling 3 (SOCS3), one of the most important inhibitory molecule of inflammatory signal transduction circuitries, could contribute to explain the pleiotropic role of interleukin-6 (IL-6) in this type of cancer.

AB - Chronic inflammation and subsequent tissutal alterations may play a key role in prostate carcinogenesis. In this way, molecular alterations of the suppressor of cytokine signaling 3 (SOCS3), one of the most important inhibitory molecule of inflammatory signal transduction circuitries, could contribute to explain the pleiotropic role of interleukin-6 (IL-6) in this type of cancer.

KW - Aged

KW - Base Sequence

KW - DNA Methylation

KW - Gene Silencing

KW - Humans

KW - Male

KW - Middle Aged

KW - Molecular Sequence Data

KW - Promoter Regions, Genetic

KW - Prostatic Hyperplasia

KW - Prostatic Neoplasms

KW - Suppressor of Cytokine Signaling Proteins

KW - Aged

KW - Base Sequence

KW - DNA Methylation

KW - Gene Silencing

KW - Humans

KW - Male

KW - Middle Aged

KW - Molecular Sequence Data

KW - Promoter Regions, Genetic

KW - Prostatic Hyperplasia

KW - Prostatic Neoplasms

KW - Suppressor of Cytokine Signaling Proteins

UR - http://hdl.handle.net/10807/2251

U2 - 10.1002/pros.21245

DO - 10.1002/pros.21245

M3 - Article

SN - 0270-4137

VL - 71

SP - 318

EP - 325

JO - THE PROSTATE

JF - THE PROSTATE

ER -

Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior

Abstract

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Keywords

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