Epigenetic modulation of RIPK3 by transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis

Alessio Vecchio; Fiorella Colasuonno; Luca Occhigrossi; Consuelo Pitolli; Veronica Bellanca; Fabio Ciccarone; Manuela D’Eletto; Federica Di Sano; Vittoria Pagliarini; Claudio Sette; Mauro Piacentini; Federica Rossin

doi:10.1007/s00018-025-05640-w

Epigenetic modulation of RIPK3 by transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis

Alessio Vecchio, Fiorella Colasuonno, Luca Occhigrossi, Consuelo Pitolli, Veronica Bellanca, Fabio Ciccarone, Manuela D’Eletto, Federica Di Sano, Vittoria Pagliarini, Claudio Sette, Mauro Piacentini, Federica Rossin

University of Rome Tor Vergata

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Transglutaminase 2 protein (TG2) is necessary to induce necroptosis. Cells lacking TG2 show a strong downregulation of Ripk3 gene. TG2 allows Ripk3 gene expression by promoting the serotonylation on H3K4me3 histone.

Lingua originale	English
pagine (da-a)	154-169
Numero di pagine	15
Rivista	Cellular and Molecular Life Sciences
Volume	82
DOI	https://doi.org/10.1007/s00018-025-05640-w
Stato di pubblicazione	Pubblicato - 2025

Keywords

H3K4me3
RIPK1
TNF
TG2
Serotonin

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10.1007/s00018-025-05640-w

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Vecchio, A., Colasuonno, F., Occhigrossi, L., Pitolli, C., Bellanca, V., Ciccarone, F., D’Eletto, M., Di Sano, F., Pagliarini, V., Sette, C., Piacentini, M., & Rossin, F. (2025). Epigenetic modulation of RIPK3 by transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis. Cellular and Molecular Life Sciences, 82, 154-169. https://doi.org/10.1007/s00018-025-05640-w

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title = "Epigenetic modulation of RIPK3 by transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis",

abstract = "Transglutaminase 2 protein (TG2) is necessary to induce necroptosis. Cells lacking TG2 show a strong downregulation of Ripk3 gene. TG2 allows Ripk3 gene expression by promoting the serotonylation on H3K4me3 histone.",

keywords = "H3K4me3, RIPK1, TNF, TG2, Serotonin, H3K4me3, RIPK1, TNF, TG2, Serotonin",

author = "Alessio Vecchio and Fiorella Colasuonno and Luca Occhigrossi and Consuelo Pitolli and Veronica Bellanca and Fabio Ciccarone and Manuela D{\textquoteright}Eletto and {Di Sano}, Federica and Vittoria Pagliarini and Claudio Sette and Mauro Piacentini and Federica Rossin",

year = "2025",

doi = "10.1007/s00018-025-05640-w",

language = "English",

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pages = "154--169",

journal = "Cellular and Molecular Life Sciences",

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Vecchio, A, Colasuonno, F, Occhigrossi, L, Pitolli, C, Bellanca, V, Ciccarone, F, D’Eletto, M, Di Sano, F, Pagliarini, V , Sette, C, Piacentini, M & Rossin, F 2025, 'Epigenetic modulation of RIPK3 by transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis', Cellular and Molecular Life Sciences, vol. 82, pagg. 154-169. https://doi.org/10.1007/s00018-025-05640-w

TY - JOUR

T1 - Epigenetic modulation of RIPK3 by transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis

AU - Vecchio, Alessio

AU - Colasuonno, Fiorella

AU - Occhigrossi, Luca

AU - Pitolli, Consuelo

AU - Bellanca, Veronica

AU - Ciccarone, Fabio

AU - D’Eletto, Manuela

AU - Di Sano, Federica

AU - Pagliarini, Vittoria

AU - Sette, Claudio

AU - Piacentini, Mauro

AU - Rossin, Federica

PY - 2025

Y1 - 2025

N2 - Transglutaminase 2 protein (TG2) is necessary to induce necroptosis. Cells lacking TG2 show a strong downregulation of Ripk3 gene. TG2 allows Ripk3 gene expression by promoting the serotonylation on H3K4me3 histone.

AB - Transglutaminase 2 protein (TG2) is necessary to induce necroptosis. Cells lacking TG2 show a strong downregulation of Ripk3 gene. TG2 allows Ripk3 gene expression by promoting the serotonylation on H3K4me3 histone.

KW - H3K4me3

KW - RIPK1

KW - TNF

KW - TG2

KW - Serotonin

KW - H3K4me3

KW - RIPK1

KW - TNF

KW - TG2

KW - Serotonin

UR - http://hdl.handle.net/10807/313377

U2 - 10.1007/s00018-025-05640-w

DO - 10.1007/s00018-025-05640-w

M3 - Article

SN - 1420-9071

VL - 82

SP - 154

EP - 169

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

ER -

Epigenetic modulation of RIPK3 by transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis

Abstract

Keywords

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