Epidemiology of intensive care unit-acquired sepsis in Italy: Results of the SPIN-UTI network

Antonella Agodi; M. Barchitta; F. Auxilia; S. Brusaferro; M. M. D'Errico; M. T. Montagna; C. Pasquarella; S. Tardivo; C. Arrigoni; L. Fabiani; Patrizia Laurenti; A. R. Mattaliano; G. B. Orsi; R. Squeri; M. V. Torregrossa; I. Mura; Mary Rose Aiello; Cristina Alliani; Maria Rita Amatucci; Manuela Antoci; Massimo Antonelli; Marinella Astuto; Luca Arnoldo; Benedetto Arru; Giorgio Baccari; Pamela Barbadoro; Andrea Barbara; Cynthia Barilaro; Pietro Battaglia; Patrizia Bellocchi; Paolo Bellocchi; Mara Olga Bernasconi; Aida Bianco; Assunta Bianco; Emanuela Bissolo; Anna Bocchi; Anna Bruno; Marco Brusaferro; Margherita Buccheri; Francesca Campanella; Rosario Canino; Antonino Cannistrà; Santa Adele Carini; Sebastiano Catalano; Paola Castellani; Giacomo Castiglione; Salvatore Coniglio; Ciriaco Consolante; Carmela Conte; Caterina Conte; Roberta Contrisciani; Rosy Corallini; Patricia Crollari; Gianfranco Damiani; Carmelo Denaro; Santa De Remigis; Francesca Diana; Rosario Di Bartolo; Antonino Di Benedetto; Gianna Di Fabio; Carlo Di Falco; Vito Digeronimo; Pietro Di Gregorio; Roberta Distefano; Giovanni Egitto; Elena Falciani; Patrizia Farruggia; Salesia Fenaroli; Giuseppe Ferlazzo; Giuseppe Garofalo; Massimo Girardis; Linda Giovanelli; Laura Giovanelli; Gabriele Giubbini; Adriana Graceffa; Antonina Guadagna; Giovanna Gregu; Franco Ingala; Ludovico Innocenzi; Giuseppa La Camera; Maria Clara La Rosa; Lucia Lesa; Anna Maria Longhitano; Giuseppe Luppino; Carmelo Massimo Maida; Giuseppe Manta; Giovanni Marino; Maria Dolores Masia; Riccardo Maviglia; Magda Mazzetti; Andrea Maugeri; Maria Teresa Megna; Laura Maria Mella; Marina Milazzo; Mario Milia; Caterina Minari; Massimo Minerva; Marco Mordacci; Paola Murgia; Pietro Oliveri; Maria Patrizia Olori; Riccardo Pagliarulo; Rosanna Palermo; Irene Pandiani; Federico Pappalardo; Cristina Papetti; Adolfo Partenza; Diana Pascu; Marcello Pasculli; Maria Pavia; Maria Luisa Pavone; Maria Giovanna Pellegrino; Maria Gabriella Pellegrino; Fabrizio Pelligra; Danila Pillon; Sergio Pintaudi; Lucia Pitzoi; Andrea Pinto; Paola Piotti; Simona Pupo; Rosalba Quattrocchi; Elena Righi; Alberto Rigo; Annalisa Rigo; Antonina Romeo; Emilio Rosa; Enrico Rosa; Serafina Rutigliano; Pierangelo Sarchi; Guglielmo Scimonello; Antonello Seminerio; Paolo Stefanini; Giovanna Sticca; Stefania Taddei; Lorella Tessari; Romano Tetamo; Mariantonietta Ticca; Salvatore Tribastoni; Sarah Vallorani; Federica Venturoni; Emilia Vitagliano; Pietro Vitali; Assunta Zappone; Ettore Zei; Maria Prudenzia Zeoli

doi:10.7416/ai.2018.2247

Epidemiology of intensive care unit-acquired sepsis in Italy: Results of the SPIN-UTI network

Antonella Agodi, M. Barchitta, F. Auxilia, S. Brusaferro, M. M. D'Errico, M. T. Montagna, C. Pasquarella, S. Tardivo, C. Arrigoni, L. Fabiani, Patrizia Laurenti, A. R. Mattaliano, G. B. Orsi, R. Squeri, M. V. Torregrossa, I. Mura, Mary Rose Aiello, Cristina Alliani, Maria Rita Amatucci, Manuela AntociMassimo Antonelli, Marinella Astuto, Luca Arnoldo, Benedetto Arru, Giorgio Baccari, Pamela Barbadoro, Andrea Barbara, Cynthia Barilaro, Pietro Battaglia, Patrizia Bellocchi, Paolo Bellocchi, Mara Olga Bernasconi, Aida Bianco, Assunta Bianco, Emanuela Bissolo, Anna Bocchi, Anna Bruno, Marco Brusaferro, Margherita Buccheri, Francesca Campanella, Rosario Canino, Antonino Cannistrà, Santa Adele Carini, Sebastiano Catalano, Paola Castellani, Giacomo Castiglione, Salvatore Coniglio, Ciriaco Consolante, Carmela Conte, Caterina Conte, Roberta Contrisciani, Rosy Corallini, Patricia Crollari, Gianfranco Damiani, Carmelo Denaro, Santa De Remigis, Francesca Diana, Rosario Di Bartolo, Antonino Di Benedetto, Gianna Di Fabio, Carlo Di Falco, Vito Digeronimo, Pietro Di Gregorio, Roberta Distefano, Giovanni Egitto, Elena Falciani, Patrizia Farruggia, Salesia Fenaroli, Giuseppe Ferlazzo, Giuseppe Garofalo, Massimo Girardis, Linda Giovanelli, Laura Giovanelli, Gabriele Giubbini, Adriana Graceffa, Antonina Guadagna, Giovanna Gregu, Franco Ingala, Ludovico Innocenzi, Giuseppa La Camera, Maria Clara La Rosa, Lucia Lesa, Anna Maria Longhitano, Giuseppe Luppino, Carmelo Massimo Maida, Giuseppe Manta, Giovanni Marino, Maria Dolores Masia, Riccardo Maviglia, Magda Mazzetti, Andrea Maugeri, Maria Teresa Megna, Laura Maria Mella, Marina Milazzo, Mario Milia, Caterina Minari, Massimo Minerva, Marco Mordacci, Paola Murgia, Pietro Oliveri, Maria Patrizia Olori, Riccardo Pagliarulo, Rosanna Palermo, Irene Pandiani, Federico Pappalardo, Cristina Papetti, Adolfo Partenza, Diana Pascu, Marcello Pasculli, Maria Pavia, Maria Luisa Pavone, Maria Giovanna Pellegrino, Maria Gabriella Pellegrino, Fabrizio Pelligra, Danila Pillon, Sergio Pintaudi, Lucia Pitzoi, Andrea Pinto, Paola Piotti, Simona Pupo, Rosalba Quattrocchi, Elena Righi, Alberto Rigo, Annalisa Rigo, Antonina Romeo, Emilio Rosa, Enrico Rosa, Serafina Rutigliano, Pierangelo Sarchi, Guglielmo Scimonello, Antonello Seminerio, Paolo Stefanini, Giovanna Sticca, Stefania Taddei, Lorella Tessari, Romano Tetamo, Mariantonietta Ticca, Salvatore Tribastoni, Sarah Vallorani, Federica Venturoni, Emilia Vitagliano, Pietro Vitali, Assunta Zappone, Ettore Zei, Maria Prudenzia Zeoli

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Background. Sepsis is the major cause of mortality from any infectious disease worldwide. Sepsis may be the result of a healthcare associated infection (HAI): the most frequent adverse events during care delivery especially in Intensive Care Units (ICUs). The main aim of the present study was to describe the epidemiology of ICU-acquired sepsis and related outcomes among patients enrolled in the framework of the Italian Nosocomial Infections Surveillance in ICUs - SPIN-UTI project. Study design. Prospective multicenter study. Methods. The SPIN-UTI network adopted the European protocols for patient-based HAI surveillance. Results. During the five editions of the SPIN-UTI project, from 2008 to 2017, 47.0% of HAIs has led to sepsis in 832 patients. Overall, 57.0% episodes were classified as sepsis, 20.5% as severe sepsis and 22.5% as septic shock. The most common isolated microorganisms from sepsis episodes were Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa. The case fatality rate increased with the severity of sepsis and the mean length of ICU-stay was significantly higher in patients with ICU-acquired sepsis than in patients without. Conclusions. Our study provides evidence that ICU-acquired sepsis occurs frequently in Italian ICU patients and is associated with a high case fatality rate and increased length of stay. However, in order to explain these findings further analyses are needed in this population of ICU patients.

Lingua originale	English
pagine (da-a)	15-21
Numero di pagine	7
Rivista	ANNALI DI IGIENE MEDICINA PREVENTIVA E DI COMUNITÀ
Volume	30
DOI	https://doi.org/10.7416/ai.2018.2247
Stato di pubblicazione	Pubblicato - 2018

Keywords

Healthcare-associated infections
Mortality Parole chiave: Infezioni correlate all'assistenza
Mortalità
Sepsi
Sepsis
Sorveglianza
Surveillance

OSS delle Nazioni Unite

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Accesso al documento

10.7416/ai.2018.2247

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Agodi, A., Barchitta, M., Auxilia, F., Brusaferro, S., D'Errico, M. M., Montagna, M. T., Pasquarella, C., Tardivo, S., Arrigoni, C., Fabiani, L., Laurenti, P., Mattaliano, A. R., Orsi, G. B., Squeri, R., Torregrossa, M. V., Mura, I., Aiello, M. R., Alliani, C., Amatucci, M. R., ... Zeoli, M. P. (2018). Epidemiology of intensive care unit-acquired sepsis in Italy: Results of the SPIN-UTI network. ANNALI DI IGIENE MEDICINA PREVENTIVA E DI COMUNITÀ, 30, 15-21. https://doi.org/10.7416/ai.2018.2247

@article{ecf759e9a72d49dbb5fe06274e5ce1de,

title = "Epidemiology of intensive care unit-acquired sepsis in Italy: Results of the SPIN-UTI network",

abstract = "Background. Sepsis is the major cause of mortality from any infectious disease worldwide. Sepsis may be the result of a healthcare associated infection (HAI): the most frequent adverse events during care delivery especially in Intensive Care Units (ICUs). The main aim of the present study was to describe the epidemiology of ICU-acquired sepsis and related outcomes among patients enrolled in the framework of the Italian Nosocomial Infections Surveillance in ICUs - SPIN-UTI project. Study design. Prospective multicenter study. Methods. The SPIN-UTI network adopted the European protocols for patient-based HAI surveillance. Results. During the five editions of the SPIN-UTI project, from 2008 to 2017, 47.0% of HAIs has led to sepsis in 832 patients. Overall, 57.0% episodes were classified as sepsis, 20.5% as severe sepsis and 22.5% as septic shock. The most common isolated microorganisms from sepsis episodes were Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa. The case fatality rate increased with the severity of sepsis and the mean length of ICU-stay was significantly higher in patients with ICU-acquired sepsis than in patients without. Conclusions. Our study provides evidence that ICU-acquired sepsis occurs frequently in Italian ICU patients and is associated with a high case fatality rate and increased length of stay. However, in order to explain these findings further analyses are needed in this population of ICU patients.",

keywords = "Healthcare-associated infections, Mortality Parole chiave: Infezioni correlate all'assistenza, Mortalit{\`a}, Sepsi, Sepsis, Sorveglianza, Surveillance, Healthcare-associated infections, Mortality Parole chiave: Infezioni correlate all'assistenza, Mortalit{\`a}, Sepsi, Sepsis, Sorveglianza, Surveillance",

author = "Antonella Agodi and M. Barchitta and F. Auxilia and S. Brusaferro and D'Errico, {M. M.} and Montagna, {M. T.} and C. Pasquarella and S. Tardivo and C. Arrigoni and L. Fabiani and Patrizia Laurenti and Mattaliano, {A. R.} and Orsi, {G. B.} and R. Squeri and Torregrossa, {M. V.} and I. Mura and Aiello, {Mary Rose} and Cristina Alliani and Amatucci, {Maria Rita} and Manuela Antoci and Massimo Antonelli and Marinella Astuto and Luca Arnoldo and Benedetto Arru and Giorgio Baccari and Pamela Barbadoro and Andrea Barbara and Cynthia Barilaro and Pietro Battaglia and Patrizia Bellocchi and Paolo Bellocchi and Bernasconi, {Mara Olga} and Aida Bianco and Assunta Bianco and Emanuela Bissolo and Anna Bocchi and Anna Bruno and Marco Brusaferro and Margherita Buccheri and Francesca Campanella and Rosario Canino and Antonino Cannistr{\`a} and Carini, {Santa Adele} and Sebastiano Catalano and Paola Castellani and Giacomo Castiglione and Salvatore Coniglio and Ciriaco Consolante and Carmela Conte and Caterina Conte and Roberta Contrisciani and Rosy Corallini and Patricia Crollari and Gianfranco Damiani and Carmelo Denaro and {De Remigis}, Santa and Francesca Diana and {Di Bartolo}, Rosario and {Di Benedetto}, Antonino and {Di Fabio}, Gianna and {Di Falco}, Carlo and Vito Digeronimo and {Di Gregorio}, Pietro and Roberta Distefano and Giovanni Egitto and Elena Falciani and Patrizia Farruggia and Salesia Fenaroli and Giuseppe Ferlazzo and Giuseppe Garofalo and Massimo Girardis and Linda Giovanelli and Laura Giovanelli and Gabriele Giubbini and Adriana Graceffa and Antonina Guadagna and Giovanna Gregu and Franco Ingala and Ludovico Innocenzi and {La Camera}, Giuseppa and {La Rosa}, {Maria Clara} and Lucia Lesa and Longhitano, {Anna Maria} and Giuseppe Luppino and Maida, {Carmelo Massimo} and Giuseppe Manta and Giovanni Marino and Masia, {Maria Dolores} and Riccardo Maviglia and Magda Mazzetti and Andrea Maugeri and Megna, {Maria Teresa} and Mella, {Laura Maria} and Marina Milazzo and Mario Milia and Caterina Minari and Massimo Minerva and Marco Mordacci and Paola Murgia and Pietro Oliveri and Olori, {Maria Patrizia} and Riccardo Pagliarulo and Rosanna Palermo and Irene Pandiani and Federico Pappalardo and Cristina Papetti and Adolfo Partenza and Diana Pascu and Marcello Pasculli and Maria Pavia and Pavone, {Maria Luisa} and Pellegrino, {Maria Giovanna} and Pellegrino, {Maria Gabriella} and Fabrizio Pelligra and Danila Pillon and Sergio Pintaudi and Lucia Pitzoi and Andrea Pinto and Paola Piotti and Simona Pupo and Rosalba Quattrocchi and Elena Righi and Alberto Rigo and Annalisa Rigo and Antonina Romeo and Emilio Rosa and Enrico Rosa and Serafina Rutigliano and Pierangelo Sarchi and Guglielmo Scimonello and Antonello Seminerio and Paolo Stefanini and Giovanna Sticca and Stefania Taddei and Lorella Tessari and Romano Tetamo and Mariantonietta Ticca and Salvatore Tribastoni and Sarah Vallorani and Federica Venturoni and Emilia Vitagliano and Pietro Vitali and Assunta Zappone and Ettore Zei and Zeoli, {Maria Prudenzia}",

year = "2018",

doi = "10.7416/ai.2018.2247",

language = "English",

volume = "30",

pages = "15--21",

journal = "Annali di igiene : medicina preventiva e di comunita",

issn = "1120-9135",

publisher = "Rome Italy: Societa Editrice Universo Srl",

}

Agodi, A, Barchitta, M, Auxilia, F, Brusaferro, S, D'Errico, MM, Montagna, MT, Pasquarella, C, Tardivo, S, Arrigoni, C, Fabiani, L, Laurenti, P, Mattaliano, AR, Orsi, GB, Squeri, R, Torregrossa, MV, Mura, I, Aiello, MR, Alliani, C, Amatucci, MR, Antoci, M, Antonelli, M, Astuto, M, Arnoldo, L, Arru, B, Baccari, G, Barbadoro, P, Barbara, A, Barilaro, C, Battaglia, P, Bellocchi, P, Bellocchi, P, Bernasconi, MO, Bianco, A, Bianco, A, Bissolo, E, Bocchi, A, Bruno, A, Brusaferro, M, Buccheri, M, Campanella, F, Canino, R, Cannistrà, A, Carini, SA, Catalano, S, Castellani, P, Castiglione, G, Coniglio, S, Consolante, C, Conte, C, Conte, C, Contrisciani, R, Corallini, R, Crollari, P, Damiani, G, Denaro, C, De Remigis, S, Diana, F, Di Bartolo, R, Di Benedetto, A, Di Fabio, G, Di Falco, C, Digeronimo, V, Di Gregorio, P, Distefano, R, Egitto, G, Falciani, E, Farruggia, P, Fenaroli, S, Ferlazzo, G, Garofalo, G, Girardis, M, Giovanelli, L, Giovanelli, L, Giubbini, G, Graceffa, A, Guadagna, A, Gregu, G, Ingala, F, Innocenzi, L, La Camera, G, La Rosa, MC, Lesa, L, Longhitano, AM, Luppino, G, Maida, CM, Manta, G, Marino, G, Masia, MD, Maviglia, R, Mazzetti, M, Maugeri, A, Megna, MT, Mella, LM, Milazzo, M, Milia, M, Minari, C, Minerva, M, Mordacci, M, Murgia, P, Oliveri, P, Olori, MP, Pagliarulo, R, Palermo, R, Pandiani, I, Pappalardo, F, Papetti, C, Partenza, A, Pascu, D, Pasculli, M, Pavia, M, Pavone, ML, Pellegrino, MG, Pellegrino, MG, Pelligra, F, Pillon, D, Pintaudi, S, Pitzoi, L, Pinto, A, Piotti, P, Pupo, S, Quattrocchi, R, Righi, E, Rigo, A, Rigo, A, Romeo, A, Rosa, E, Rosa, E, Rutigliano, S, Sarchi, P, Scimonello, G, Seminerio, A, Stefanini, P, Sticca, G, Taddei, S, Tessari, L, Tetamo, R, Ticca, M, Tribastoni, S, Vallorani, S, Venturoni, F, Vitagliano, E, Vitali, P, Zappone, A, Zei, E & Zeoli, MP 2018, 'Epidemiology of intensive care unit-acquired sepsis in Italy: Results of the SPIN-UTI network', ANNALI DI IGIENE MEDICINA PREVENTIVA E DI COMUNITÀ, vol. 30, pagg. 15-21. https://doi.org/10.7416/ai.2018.2247

TY - JOUR

T1 - Epidemiology of intensive care unit-acquired sepsis in Italy: Results of the SPIN-UTI network

AU - Agodi, Antonella

AU - Barchitta, M.

AU - Auxilia, F.

AU - Brusaferro, S.

AU - D'Errico, M. M.

AU - Montagna, M. T.

AU - Pasquarella, C.

AU - Tardivo, S.

AU - Arrigoni, C.

AU - Fabiani, L.

AU - Laurenti, Patrizia

AU - Mattaliano, A. R.

AU - Orsi, G. B.

AU - Squeri, R.

AU - Torregrossa, M. V.

AU - Mura, I.

AU - Aiello, Mary Rose

AU - Alliani, Cristina

AU - Amatucci, Maria Rita

AU - Antoci, Manuela

AU - Antonelli, Massimo

AU - Astuto, Marinella

AU - Arnoldo, Luca

AU - Arru, Benedetto

AU - Baccari, Giorgio

AU - Barbadoro, Pamela

AU - Barbara, Andrea

AU - Barilaro, Cynthia

AU - Battaglia, Pietro

AU - Bellocchi, Patrizia

AU - Bellocchi, Paolo

AU - Bernasconi, Mara Olga

AU - Bianco, Aida

AU - Bianco, Assunta

AU - Bissolo, Emanuela

AU - Bocchi, Anna

AU - Bruno, Anna

AU - Brusaferro, Marco

AU - Buccheri, Margherita

AU - Campanella, Francesca

AU - Canino, Rosario

AU - Cannistrà, Antonino

AU - Carini, Santa Adele

AU - Catalano, Sebastiano

AU - Castellani, Paola

AU - Castiglione, Giacomo

AU - Coniglio, Salvatore

AU - Consolante, Ciriaco

AU - Conte, Carmela

AU - Conte, Caterina

AU - Contrisciani, Roberta

AU - Corallini, Rosy

AU - Crollari, Patricia

AU - Damiani, Gianfranco

AU - Denaro, Carmelo

AU - De Remigis, Santa

AU - Diana, Francesca

AU - Di Bartolo, Rosario

AU - Di Benedetto, Antonino

AU - Di Fabio, Gianna

AU - Di Falco, Carlo

AU - Digeronimo, Vito

AU - Di Gregorio, Pietro

AU - Distefano, Roberta

AU - Egitto, Giovanni

AU - Falciani, Elena

AU - Farruggia, Patrizia

AU - Fenaroli, Salesia

AU - Ferlazzo, Giuseppe

AU - Garofalo, Giuseppe

AU - Girardis, Massimo

AU - Giovanelli, Linda

AU - Giovanelli, Laura

AU - Giubbini, Gabriele

AU - Graceffa, Adriana

AU - Guadagna, Antonina

AU - Gregu, Giovanna

AU - Ingala, Franco

AU - Innocenzi, Ludovico

AU - La Camera, Giuseppa

AU - La Rosa, Maria Clara

AU - Lesa, Lucia

AU - Longhitano, Anna Maria

AU - Luppino, Giuseppe

AU - Maida, Carmelo Massimo

AU - Manta, Giuseppe

AU - Marino, Giovanni

AU - Masia, Maria Dolores

AU - Maviglia, Riccardo

AU - Mazzetti, Magda

AU - Maugeri, Andrea

AU - Megna, Maria Teresa

AU - Mella, Laura Maria

AU - Milazzo, Marina

AU - Milia, Mario

AU - Minari, Caterina

AU - Minerva, Massimo

AU - Mordacci, Marco

AU - Murgia, Paola

AU - Oliveri, Pietro

AU - Olori, Maria Patrizia

AU - Pagliarulo, Riccardo

AU - Palermo, Rosanna

AU - Pandiani, Irene

AU - Pappalardo, Federico

AU - Papetti, Cristina

AU - Partenza, Adolfo

AU - Pascu, Diana

AU - Pasculli, Marcello

AU - Pavia, Maria

AU - Pavone, Maria Luisa

AU - Pellegrino, Maria Giovanna

AU - Pellegrino, Maria Gabriella

AU - Pelligra, Fabrizio

AU - Pillon, Danila

AU - Pintaudi, Sergio

AU - Pitzoi, Lucia

AU - Pinto, Andrea

AU - Piotti, Paola

AU - Pupo, Simona

AU - Quattrocchi, Rosalba

AU - Righi, Elena

AU - Rigo, Alberto

AU - Rigo, Annalisa

AU - Romeo, Antonina

AU - Rosa, Emilio

AU - Rosa, Enrico

AU - Rutigliano, Serafina

AU - Sarchi, Pierangelo

AU - Scimonello, Guglielmo

AU - Seminerio, Antonello

AU - Stefanini, Paolo

AU - Sticca, Giovanna

AU - Taddei, Stefania

AU - Tessari, Lorella

AU - Tetamo, Romano

AU - Ticca, Mariantonietta

AU - Tribastoni, Salvatore

AU - Vallorani, Sarah

AU - Venturoni, Federica

AU - Vitagliano, Emilia

AU - Vitali, Pietro

AU - Zappone, Assunta

AU - Zei, Ettore

AU - Zeoli, Maria Prudenzia

PY - 2018

Y1 - 2018

N2 - Background. Sepsis is the major cause of mortality from any infectious disease worldwide. Sepsis may be the result of a healthcare associated infection (HAI): the most frequent adverse events during care delivery especially in Intensive Care Units (ICUs). The main aim of the present study was to describe the epidemiology of ICU-acquired sepsis and related outcomes among patients enrolled in the framework of the Italian Nosocomial Infections Surveillance in ICUs - SPIN-UTI project. Study design. Prospective multicenter study. Methods. The SPIN-UTI network adopted the European protocols for patient-based HAI surveillance. Results. During the five editions of the SPIN-UTI project, from 2008 to 2017, 47.0% of HAIs has led to sepsis in 832 patients. Overall, 57.0% episodes were classified as sepsis, 20.5% as severe sepsis and 22.5% as septic shock. The most common isolated microorganisms from sepsis episodes were Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa. The case fatality rate increased with the severity of sepsis and the mean length of ICU-stay was significantly higher in patients with ICU-acquired sepsis than in patients without. Conclusions. Our study provides evidence that ICU-acquired sepsis occurs frequently in Italian ICU patients and is associated with a high case fatality rate and increased length of stay. However, in order to explain these findings further analyses are needed in this population of ICU patients.

AB - Background. Sepsis is the major cause of mortality from any infectious disease worldwide. Sepsis may be the result of a healthcare associated infection (HAI): the most frequent adverse events during care delivery especially in Intensive Care Units (ICUs). The main aim of the present study was to describe the epidemiology of ICU-acquired sepsis and related outcomes among patients enrolled in the framework of the Italian Nosocomial Infections Surveillance in ICUs - SPIN-UTI project. Study design. Prospective multicenter study. Methods. The SPIN-UTI network adopted the European protocols for patient-based HAI surveillance. Results. During the five editions of the SPIN-UTI project, from 2008 to 2017, 47.0% of HAIs has led to sepsis in 832 patients. Overall, 57.0% episodes were classified as sepsis, 20.5% as severe sepsis and 22.5% as septic shock. The most common isolated microorganisms from sepsis episodes were Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa. The case fatality rate increased with the severity of sepsis and the mean length of ICU-stay was significantly higher in patients with ICU-acquired sepsis than in patients without. Conclusions. Our study provides evidence that ICU-acquired sepsis occurs frequently in Italian ICU patients and is associated with a high case fatality rate and increased length of stay. However, in order to explain these findings further analyses are needed in this population of ICU patients.

KW - Healthcare-associated infections

KW - Mortality Parole chiave: Infezioni correlate all'assistenza

KW - Mortalità

KW - Sepsi

KW - Sepsis

KW - Sorveglianza

KW - Surveillance

KW - Healthcare-associated infections

KW - Mortality Parole chiave: Infezioni correlate all'assistenza

KW - Mortalità

KW - Sepsi

KW - Sepsis

KW - Sorveglianza

KW - Surveillance

UR - http://hdl.handle.net/10807/203216

U2 - 10.7416/ai.2018.2247

DO - 10.7416/ai.2018.2247

M3 - Article

SN - 1120-9135

VL - 30

SP - 15

EP - 21

JO - Annali di igiene : medicina preventiva e di comunita

JF - Annali di igiene : medicina preventiva e di comunita

ER -

Epidemiology of intensive care unit-acquired sepsis in Italy: Results of the SPIN-UTI network

Abstract

Keywords

OSS delle Nazioni Unite

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