Eosinophilic Esophagitis During Latex Desensitization

Latex allergy is a relevant clinical problem observed especially among health-care workers, spina bifida patients and individuals who had multiple surgical procedures. Type I hypersensitivity latex reactions are more frequent than type IV (latex allergic contact dermatitis) and consist of skin involvement (urticaria and/or angioedema), respiratory symptoms (asthma/rhinitis) to systemic anaphylaxis. Thoseare elicited by direct contact with natural rubber latex items (i.e. medical devices) or by inhalation of latex airborne proteins. After diagnosis, prevention is the standard and best measure, but the strict avoidance is often impossible. Therefore in selected cases, the sublingual immunotherapy (SLIT) may be a therapeutic approach able to influence the long-term natural history of latex allergy [1]. During SLIT, immediate adverse reactions have often been reported [2], but long-term complication are less described. We showed the case of an eosinophilic esophagitis (EoE) occurring after 3 years of latex SLIT