Eosinophil cationic protein and clinical outcome after bare metal stent implantation

Carlo Trani; Francesco Burzotta; Filippo Crea; Giampaolo Niccoli; Gregory Angelo Sgueglia; Micaela Conte; Nicola Cosentino; Flavia Belloni; Vito Sabato; Italo Porto; Antonio Maria Leone; Domenico Schiavino; Silvia Minelli

doi:21183182

Eosinophil cationic protein and clinical outcome after bare metal stent implantation

Carlo Trani, Francesco Burzotta, Filippo Crea, Giampaolo Niccoli, Gregory Angelo Sgueglia, Micaela Conte, Nicola Cosentino, Flavia Belloni, Vito Sabato, Italo Porto, Antonio Maria Leone, Domenico Schiavino, Silvia Minelli

Risultato della ricerca: Contributo in rivista › Articolo in rivista

26 Citazioni (Scopus)

Abstract

Objective: we assessed the association between baseline eosinophil cationic protein (ECP) levels, a sensitive marker of eosinophil activation, and clinical outcome in patients undergoing bare metal stent (BMS) implantation. Methods: basal ECP levels were measured in 110 patients (69±11 years, 88 men) undergoingBMSimplantation. Major adverse cardiac events (MACEs), defined as cardiac death, non-fatal myocardial infarction, or clinically-driven target lesion revascularization, were registered at 24-month follow-up. Results: eighteen (16.4%) patients had MACEs and showed higher ECP levels compared with those without MACEs [20.1 (9.8 47.3) vs. 9.5 (5.0 27.2) g/L, p = 0.02]. At follow-up, ECP level >11 g/L was the only significant predictor of MACEs (HR 3.5, 95% CI 1.1 10.4, p = 0.03). Conclusion: basal ECP levels are associated with MACEs after BMS implantation, suggesting that an allergic-mediated inflammation against the metal could explain some adverse reactions occurring after coronary stenting.

Lingua originale	English
pagine (da-a)	166-169
Numero di pagine	4
Rivista	ATHEROSCLEROSIS
Volume	215
DOI	https://doi.org/21183182
Stato di pubblicazione	Pubblicato - 2011

Keywords

Bare metal stents
Eosinophil cationic protein
Eosinophils
Prognosis

Accesso al documento

21183182

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Trani, Carlo ; Burzotta, Francesco ; Crea, Filippo ; Niccoli, Giampaolo ; Sgueglia, Gregory Angelo ; Conte, Micaela ; Cosentino, Nicola ; Belloni, Flavia ; Sabato, Vito ; Porto, Italo ; Leone, Antonio Maria ; Schiavino, Domenico ; Minelli, Silvia. / Eosinophil cationic protein and clinical outcome after bare metal stent implantation. In: ATHEROSCLEROSIS. 2011 ; Vol. 215. pagg. 166-169.

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title = "Eosinophil cationic protein and clinical outcome after bare metal stent implantation",

abstract = "Objective: we assessed the association between baseline eosinophil cationic protein (ECP) levels, a sensitive marker of eosinophil activation, and clinical outcome in patients undergoing bare metal stent (BMS) implantation. Methods: basal ECP levels were measured in 110 patients (69±11 years, 88 men) undergoingBMSimplantation. Major adverse cardiac events (MACEs), defined as cardiac death, non-fatal myocardial infarction, or clinically-driven target lesion revascularization, were registered at 24-month follow-up. Results: eighteen (16.4%) patients had MACEs and showed higher ECP levels compared with those without MACEs [20.1 (9.8 47.3) vs. 9.5 (5.0 27.2) g/L, p = 0.02]. At follow-up, ECP level >11 g/L was the only significant predictor of MACEs (HR 3.5, 95% CI 1.1 10.4, p = 0.03). Conclusion: basal ECP levels are associated with MACEs after BMS implantation, suggesting that an allergic-mediated inflammation against the metal could explain some adverse reactions occurring after coronary stenting.",

keywords = "Bare metal stents, Eosinophil cationic protein, Eosinophils, Prognosis, Bare metal stents, Eosinophil cationic protein, Eosinophils, Prognosis",

author = "Carlo Trani and Francesco Burzotta and Filippo Crea and Giampaolo Niccoli and Sgueglia, {Gregory Angelo} and Micaela Conte and Nicola Cosentino and Flavia Belloni and Vito Sabato and Italo Porto and Leone, {Antonio Maria} and Domenico Schiavino and Silvia Minelli",

year = "2011",

doi = "21183182",

language = "English",

volume = "215",

pages = "166--169",

journal = "ATHEROSCLEROSIS",

issn = "0021-9150",

publisher = "Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114",

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Eosinophil cationic protein and clinical outcome after bare metal stent implantation. / Trani, Carlo ; Burzotta, Francesco ; Crea, Filippo; Niccoli, Giampaolo; Sgueglia, Gregory Angelo; Conte, Micaela; Cosentino, Nicola; Belloni, Flavia; Sabato, Vito; Porto, Italo; Leone, Antonio Maria; Schiavino, Domenico; Minelli, Silvia.

In: ATHEROSCLEROSIS, Vol. 215, 2011, pag. 166-169.

Risultato della ricerca: Contributo in rivista › Articolo in rivista

TY - JOUR

T1 - Eosinophil cationic protein and clinical outcome after bare metal stent implantation

AU - Trani, Carlo

AU - Burzotta, Francesco

AU - Crea, Filippo

AU - Niccoli, Giampaolo

AU - Sgueglia, Gregory Angelo

AU - Conte, Micaela

AU - Cosentino, Nicola

AU - Belloni, Flavia

AU - Sabato, Vito

AU - Porto, Italo

AU - Leone, Antonio Maria

AU - Schiavino, Domenico

AU - Minelli, Silvia

PY - 2011

Y1 - 2011

N2 - Objective: we assessed the association between baseline eosinophil cationic protein (ECP) levels, a sensitive marker of eosinophil activation, and clinical outcome in patients undergoing bare metal stent (BMS) implantation. Methods: basal ECP levels were measured in 110 patients (69±11 years, 88 men) undergoingBMSimplantation. Major adverse cardiac events (MACEs), defined as cardiac death, non-fatal myocardial infarction, or clinically-driven target lesion revascularization, were registered at 24-month follow-up. Results: eighteen (16.4%) patients had MACEs and showed higher ECP levels compared with those without MACEs [20.1 (9.8 47.3) vs. 9.5 (5.0 27.2) g/L, p = 0.02]. At follow-up, ECP level >11 g/L was the only significant predictor of MACEs (HR 3.5, 95% CI 1.1 10.4, p = 0.03). Conclusion: basal ECP levels are associated with MACEs after BMS implantation, suggesting that an allergic-mediated inflammation against the metal could explain some adverse reactions occurring after coronary stenting.

AB - Objective: we assessed the association between baseline eosinophil cationic protein (ECP) levels, a sensitive marker of eosinophil activation, and clinical outcome in patients undergoing bare metal stent (BMS) implantation. Methods: basal ECP levels were measured in 110 patients (69±11 years, 88 men) undergoingBMSimplantation. Major adverse cardiac events (MACEs), defined as cardiac death, non-fatal myocardial infarction, or clinically-driven target lesion revascularization, were registered at 24-month follow-up. Results: eighteen (16.4%) patients had MACEs and showed higher ECP levels compared with those without MACEs [20.1 (9.8 47.3) vs. 9.5 (5.0 27.2) g/L, p = 0.02]. At follow-up, ECP level >11 g/L was the only significant predictor of MACEs (HR 3.5, 95% CI 1.1 10.4, p = 0.03). Conclusion: basal ECP levels are associated with MACEs after BMS implantation, suggesting that an allergic-mediated inflammation against the metal could explain some adverse reactions occurring after coronary stenting.

KW - Bare metal stents

KW - Eosinophil cationic protein

KW - Eosinophils

KW - Prognosis

KW - Bare metal stents

KW - Eosinophil cationic protein

KW - Eosinophils

KW - Prognosis

UR - http://hdl.handle.net/10807/13701

U2 - 21183182

DO - 21183182

M3 - Article

VL - 215

SP - 166

EP - 169

JO - ATHEROSCLEROSIS

JF - ATHEROSCLEROSIS

SN - 0021-9150

ER -