Eosinophil cationic protein and clinical outcome after bare metal stent implantation

Carlo Trani, Francesco Burzotta, Filippo Crea, Giampaolo Niccoli, Gregory Angelo Sgueglia, Micaela Conte, Nicola Cosentino, Flavia Belloni, Vito Sabato, Italo Porto, Antonio Maria Leone, Domenico Schiavino, Silvia Minelli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

26 Citazioni (Scopus)

Abstract

Objective: we assessed the association between baseline eosinophil cationic protein (ECP) levels, a sensitive marker of eosinophil activation, and clinical outcome in patients undergoing bare metal stent (BMS) implantation. Methods: basal ECP levels were measured in 110 patients (69±11 years, 88 men) undergoingBMSimplantation. Major adverse cardiac events (MACEs), defined as cardiac death, non-fatal myocardial infarction, or clinically-driven target lesion revascularization, were registered at 24-month follow-up. Results: eighteen (16.4%) patients had MACEs and showed higher ECP levels compared with those without MACEs [20.1 (9.8 47.3) vs. 9.5 (5.0 27.2) g/L, p = 0.02]. At follow-up, ECP level >11 g/L was the only significant predictor of MACEs (HR 3.5, 95% CI 1.1 10.4, p = 0.03). Conclusion: basal ECP levels are associated with MACEs after BMS implantation, suggesting that an allergic-mediated inflammation against the metal could explain some adverse reactions occurring after coronary stenting.
Lingua originaleEnglish
pagine (da-a)166-169
Numero di pagine4
RivistaATHEROSCLEROSIS
Volume215
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Bare metal stents
  • Eosinophil cationic protein
  • Eosinophils
  • Prognosis

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