Eosinophil cationic protein and clinical outcome after bare metal stent implantation

Giampaolo Niccoli; Gregory Angelo Sgueglia; Micaela Conte; Nicola Cosentino; Silvia Minelli; Flavia Belloni; Carlo Trani; Vito Sabato; Francesco Burzotta; Italo Porto; Antonio Maria Leone; Domenico Schiavino; Filippo Crea

doi:10.1016/j.atherosclerosis.2010.11.044

Eosinophil cationic protein and clinical outcome after bare metal stent implantation

Giampaolo Niccoli, Gregory Angelo Sgueglia, Micaela Conte, Nicola Cosentino, Silvia Minelli, Flavia Belloni, Carlo Trani, Vito Sabato, Francesco Burzotta, Italo Porto, Antonio Maria Leone, Domenico Schiavino, Filippo Crea

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

27 Citazioni (Scopus)

Abstract

we assessed the association between baseline eosinophil cationic protein (ECP) levels, a sensitive marker of eosinophil activation, and clinical outcome in patients undergoing bare metal stent (BMS) implantation. METHODS: basal ECP levels were measured in 110 patients (69±11 years, 88 men) undergoing BMS implantation. Major adverse cardiac events (MACEs), defined as cardiac death, non-fatal myocardial infarction, or clinically-driven target lesion revascularization, were registered at 24-month follow-up. RESULTS: eighteen (16.4%) patients had MACEs and showed higher ECP levels compared with those without MACEs [20.1 (9.8-47.3) vs. 9.5 (5.0-27.2) g/L, p=0.02]. At follow-up, ECP level>11 g/L was the only significant predictor of MACEs (HR 3.5, 95% CI 1.1-10.4, p=0.03). CONCLUSION: basal ECP levels are associated with MACEs after BMS implantation, suggesting that an allergic-mediated inflammation against the metal could explain some adverse reactions occurring after coronary stenting.

Lingua originale	English
pagine (da-a)	166-169
Numero di pagine	4
Rivista	Atherosclerosis
DOI	https://doi.org/10.1016/j.atherosclerosis.2010.11.044
Stato di pubblicazione	Pubblicato - 2011

Keywords

Bare metal stents
Eosinophils

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10.1016/j.atherosclerosis.2010.11.044

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title = "Eosinophil cationic protein and clinical outcome after bare metal stent implantation",

abstract = "we assessed the association between baseline eosinophil cationic protein (ECP) levels, a sensitive marker of eosinophil activation, and clinical outcome in patients undergoing bare metal stent (BMS) implantation. METHODS: basal ECP levels were measured in 110 patients (69±11 years, 88 men) undergoing BMS implantation. Major adverse cardiac events (MACEs), defined as cardiac death, non-fatal myocardial infarction, or clinically-driven target lesion revascularization, were registered at 24-month follow-up. RESULTS: eighteen (16.4%) patients had MACEs and showed higher ECP levels compared with those without MACEs [20.1 (9.8-47.3) vs. 9.5 (5.0-27.2) g/L, p=0.02]. At follow-up, ECP level>11 g/L was the only significant predictor of MACEs (HR 3.5, 95% CI 1.1-10.4, p=0.03). CONCLUSION: basal ECP levels are associated with MACEs after BMS implantation, suggesting that an allergic-mediated inflammation against the metal could explain some adverse reactions occurring after coronary stenting.",

keywords = "Bare metal stents, Eosinophils, Bare metal stents, Eosinophils",

author = "Giampaolo Niccoli and Sgueglia, {Gregory Angelo} and Micaela Conte and Nicola Cosentino and Silvia Minelli and Flavia Belloni and Carlo Trani and Vito Sabato and Francesco Burzotta and Italo Porto and Leone, {Antonio Maria} and Domenico Schiavino and Filippo Crea",

year = "2011",

doi = "10.1016/j.atherosclerosis.2010.11.044",

language = "English",

pages = "166--169",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: [email protected], INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114",

}

TY - JOUR

T1 - Eosinophil cationic protein and clinical outcome after bare metal stent implantation

AU - Niccoli, Giampaolo

AU - Sgueglia, Gregory Angelo

AU - Conte, Micaela

AU - Cosentino, Nicola

AU - Minelli, Silvia

AU - Belloni, Flavia

AU - Trani, Carlo

AU - Sabato, Vito

AU - Burzotta, Francesco

AU - Porto, Italo

AU - Leone, Antonio Maria

AU - Schiavino, Domenico

AU - Crea, Filippo

PY - 2011

Y1 - 2011

N2 - we assessed the association between baseline eosinophil cationic protein (ECP) levels, a sensitive marker of eosinophil activation, and clinical outcome in patients undergoing bare metal stent (BMS) implantation. METHODS: basal ECP levels were measured in 110 patients (69±11 years, 88 men) undergoing BMS implantation. Major adverse cardiac events (MACEs), defined as cardiac death, non-fatal myocardial infarction, or clinically-driven target lesion revascularization, were registered at 24-month follow-up. RESULTS: eighteen (16.4%) patients had MACEs and showed higher ECP levels compared with those without MACEs [20.1 (9.8-47.3) vs. 9.5 (5.0-27.2) g/L, p=0.02]. At follow-up, ECP level>11 g/L was the only significant predictor of MACEs (HR 3.5, 95% CI 1.1-10.4, p=0.03). CONCLUSION: basal ECP levels are associated with MACEs after BMS implantation, suggesting that an allergic-mediated inflammation against the metal could explain some adverse reactions occurring after coronary stenting.

AB - we assessed the association between baseline eosinophil cationic protein (ECP) levels, a sensitive marker of eosinophil activation, and clinical outcome in patients undergoing bare metal stent (BMS) implantation. METHODS: basal ECP levels were measured in 110 patients (69±11 years, 88 men) undergoing BMS implantation. Major adverse cardiac events (MACEs), defined as cardiac death, non-fatal myocardial infarction, or clinically-driven target lesion revascularization, were registered at 24-month follow-up. RESULTS: eighteen (16.4%) patients had MACEs and showed higher ECP levels compared with those without MACEs [20.1 (9.8-47.3) vs. 9.5 (5.0-27.2) g/L, p=0.02]. At follow-up, ECP level>11 g/L was the only significant predictor of MACEs (HR 3.5, 95% CI 1.1-10.4, p=0.03). CONCLUSION: basal ECP levels are associated with MACEs after BMS implantation, suggesting that an allergic-mediated inflammation against the metal could explain some adverse reactions occurring after coronary stenting.

KW - Bare metal stents

KW - Eosinophils

KW - Bare metal stents

KW - Eosinophils

UR - http://hdl.handle.net/10807/7010

U2 - 10.1016/j.atherosclerosis.2010.11.044

DO - 10.1016/j.atherosclerosis.2010.11.044

M3 - Article

SN - 0021-9150

SP - 166

EP - 169

JO - Atherosclerosis

JF - Atherosclerosis

ER -

Eosinophil cationic protein and clinical outcome after bare metal stent implantation

Abstract

Keywords

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