Enuresis, incontinence, urodynamic findings and glycosaminoglycan urinary excretion

Objective - To determine quantitative variations of glycosaminoglycan urinary excretion and urodynamic findings in children affected with nocturnal enuresis and/or diurnal incontinence. Patients and methods - Glycosaminoglycan urinary excretion and cystomanometry has been measured in children with nocturnal enuresis and/or diurnal incontinence, aged 5-15 years, and in 27 age-matched healthy controls through carbazole-tetraborate method. Results - Children with nocturnal enuresis and diurnal incontinence have showed higher values of glycosaminoglycan urinary excretion as opposed to healthy children. Moreover a statistically significant difference has been observed between quantities excreted in enuretic and incontinent children as opposed to only enuretic ones. In patients with nocturnal enuresis and diurnal incontinence there was an alteration of urodynamic findings. Conclusions - On the basis of our preliminar results it is evidenced that urinary glycosaminoglycans and cistimanometry may constitute a useful marker for evaluating bladder wall physiopathology and for monitoring a potential damage at a mucosal level in a large number of subjects.