Enuresis in childhood and bladder cancer in adulthood: Is there "a bridge" that joins?

Introduction The rising incidence of urinary bladder cancer is alarming and potential relationship with micturition disorders have been postulated and incontinence is one of bladder cancer symptoms. We investigate whether exists a possible correlation between bladder cancer occurring in adulthood and a positive history of nocturnal enuresis (NE) in childhood. Materials and methods We retrospectively reviewed a cohort of 100 patients affected by bladder cancer of different grading and staging. All patients were interviewed about voiding disorders during their childhood. Results Four patients suffered from NE during childhood. Of those, 3/4 were affected by urothelial cell cancer (all graded low grade) and 1/4 was affected by keratinizing squamocellular carcinoma (graded G3) Conclusion Our study suggests that there is not a sure correlation between micturition disorders such as NE in childhood and the bladder cancer’s pathogenesis in adulthood.