Enterococcus faecium PBP5-S/R, the missing link between PBP5-S and PBP5-R.

Pier Sandro Cocconcelli, Ester Pietta, Maria Camila Montealegre, Jung Hyeob Roh, Barbara E. Murray

Risultato della ricerca: Contributo in rivistaArticolo in rivista

13 Citazioni (Scopus)

Abstract

Abstract During a study to investigate the evolution of ampicillin resistance in Enterococcus faecium, we observed that a number of E. faecium strains, mainly from the recently described subclade A2, showed PBP5 sequences in between PBP5-S and PBP5-R. These hybrid PBP5-S/R patterns reveal a progression of amino acid changes from the S form to the R form of this protein; however, these changes do not strictly correlate with changes in ampicillin MICs.
Lingua originaleEnglish
pagine (da-a)6978-6981
Numero di pagine4
RivistaAntimicrobial Agents and Chemotherapy
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Enterococcus faecium
  • PBP5-R
  • PBP5-S

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