Enhanced sensitivity to oxidative stress in Cu,ZnSOD depleted rat erythrocytes.

Paola Palozza; Gm Bartoli; E. Piccioni

Enhanced sensitivity to oxidative stress in Cu,ZnSOD depleted rat erythrocytes.

Paola Palozza, Gm Bartoli, E. Piccioni

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

Abstract

The effects on red blood cells of superoxide dismutase (Cu,ZnSOD) depletion, induced by feeding Wistar rats with a copper deficient diet, were investigated. SOD depleted red blood cells were more sensitive to peroxidation and to hemolysis than normal cells when exposed to tert-butylhydroperoxide (t-BOOH). Membranes isolated from SOD depleted cells showed a lower content of vitamin E and higher (Na+, K+) and Mg2+ ATPase activities. These results support the view that superoxide dismutase plays an important role in cellular oxidative metabolism.

Lingua originale	English
pagine (da-a)	291-295
Numero di pagine	5
Rivista	BIOCHIMICA ET BIOPHYSICA ACTA
Stato di pubblicazione	Pubblicato - 1992
Pubblicato esternamente	Sì

Keywords

CuZnSOD
oxidative stress

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title = "Enhanced sensitivity to oxidative stress in Cu,ZnSOD depleted rat erythrocytes.",

abstract = "The effects on red blood cells of superoxide dismutase (Cu,ZnSOD) depletion, induced by feeding Wistar rats with a copper deficient diet, were investigated. SOD depleted red blood cells were more sensitive to peroxidation and to hemolysis than normal cells when exposed to tert-butylhydroperoxide (t-BOOH). Membranes isolated from SOD depleted cells showed a lower content of vitamin E and higher (Na+, K+) and Mg2+ ATPase activities. These results support the view that superoxide dismutase plays an important role in cellular oxidative metabolism.",

keywords = "CuZnSOD, oxidative stress, CuZnSOD, oxidative stress",

author = "Paola Palozza and Gm Bartoli and E. Piccioni",

year = "1992",

language = "English",

pages = "291--295",

journal = "BIOCHIMICA ET BIOPHYSICA ACTA",

issn = "0006-3002",

publisher = "Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: [email protected], INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598",

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TY - JOUR

T1 - Enhanced sensitivity to oxidative stress in Cu,ZnSOD depleted rat erythrocytes.

AU - Palozza, Paola

AU - Bartoli, Gm

AU - Piccioni, E.

PY - 1992

Y1 - 1992

N2 - The effects on red blood cells of superoxide dismutase (Cu,ZnSOD) depletion, induced by feeding Wistar rats with a copper deficient diet, were investigated. SOD depleted red blood cells were more sensitive to peroxidation and to hemolysis than normal cells when exposed to tert-butylhydroperoxide (t-BOOH). Membranes isolated from SOD depleted cells showed a lower content of vitamin E and higher (Na+, K+) and Mg2+ ATPase activities. These results support the view that superoxide dismutase plays an important role in cellular oxidative metabolism.

AB - The effects on red blood cells of superoxide dismutase (Cu,ZnSOD) depletion, induced by feeding Wistar rats with a copper deficient diet, were investigated. SOD depleted red blood cells were more sensitive to peroxidation and to hemolysis than normal cells when exposed to tert-butylhydroperoxide (t-BOOH). Membranes isolated from SOD depleted cells showed a lower content of vitamin E and higher (Na+, K+) and Mg2+ ATPase activities. These results support the view that superoxide dismutase plays an important role in cellular oxidative metabolism.

KW - CuZnSOD

KW - oxidative stress

KW - CuZnSOD

KW - oxidative stress

UR - http://hdl.handle.net/10807/20157

M3 - Article

SN - 0006-3002

SP - 291

EP - 295

JO - BIOCHIMICA ET BIOPHYSICA ACTA

JF - BIOCHIMICA ET BIOPHYSICA ACTA

ER -

Enhanced sensitivity to oxidative stress in Cu,ZnSOD depleted rat erythrocytes.

Abstract

Keywords

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