Enhanced sensitivity to oxidative stress in Cu,ZnSOD depleted rat erythrocytes.

Paola Palozza, Bartoli Gm, E. Piccioni

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

8 Citazioni (Scopus)

Abstract

The effects on red blood cells of superoxide dismutase (Cu,ZnSOD) depletion, induced by feeding Wistar rats with a copper deficient diet, were investigated. SOD depleted red blood cells were more sensitive to peroxidation and to hemolysis than normal cells when exposed to tert-butylhydroperoxide (t-BOOH). Membranes isolated from SOD depleted cells showed a lower content of vitamin E and higher (Na+, K+) and Mg2+ ATPase activities. These results support the view that superoxide dismutase plays an important role in cellular oxidative metabolism.
Lingua originaleEnglish
pagine (da-a)291-295
Numero di pagine5
RivistaBIOCHIMICA ET BIOPHYSICA ACTA
Stato di pubblicazionePubblicato - 1992
Pubblicato esternamente

Keywords

  • CuZnSOD
  • oxidative stress

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