Enhanced liver fibrosis test as a reliable tool for assessing fibrosis in nonalcoholic fatty liver disease in a clinical setting

Luca Miele, Antonio Gasbarrini, Antonio Grieco, Teresa De Michele, Giuseppe Marrone, Maria Antonietta Isgro', Umberto Basile, Consuelo Cefalo, Marco Biolato, Fabio Maria Vecchio, Cecilia Zuppi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

10 Citazioni (Scopus)

Abstract

Background: Liver fibrosis is the main determinant and predictor of the clinical course of nonalcoholic fatty liver disease (NAFLD). To date, a liver biopsy is still considered the gold standard for staging fibrosis. The aim of this study was to investigate the diagnostic accuracy of the commercial enhanced liver fibrosis (ELF) test manufacturer’s cutoff value (≥9.8) in identifying severe fibrosis for adult patients with histologically confirmed NAFLD. Methods: We tested the ELF test in a clinical practice, prospective cohort of 82 consecutive patients who consecutively underwent percutaneous liver biopsy. Results: All stages of liver fibrosis were represented in our cohort, and severe fibrosis was present in 15 of 82 patients (18.3%). The stage of fibrosis was significantly associated with ELF score (Spearman’s rho = 0.483, p<0.001). The commercial ELF test manufacturer’s cutoff identified severe fibrosis with good sensitivity (86.7%; 95% confidence interval [95% CI], 0.69-1.04) and high specificity (92.5%; 95% CI, 0.86-0.99), with a positive predictive value of 72% and negative predictive value of 97%. Conclusions: Our data could support the use of the ELF test in clinical practice.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaTHE INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS
Volume32
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • 2734
  • Cancer Research
  • Clinical Biochemistry
  • ELF test
  • Liver biopsy
  • Liver fibrosis
  • NAFLD
  • NASH
  • Oncology
  • Serum markers

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