Enhanced BDNF serum levels in patients with severe pathological gambling

Giovanni Martinotti, Elisabetta Righino, Gianluigi Conte, Pietro Bria, Valerio Ricci, F Angelucci, F Gelfo, C Caltagirone

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Although the pathophysiology of gambling is unknown, an involvement of midbrain dopaminergic pathway has been hypothesized. In this study, the association between brain-derived neurotrophic factor (BDNF) and pathological gambling was investigated. We measured BDNF serum levels in (1) video players (n = 10); (2) card players (n = 9); (3) mixed players (n = 21; both video and card players) and (4) age-matched controls (n = 18). Mixed players had increased BDNF serum levels as compared to controls and higher South Oaks Gambling Screen score as compared to card or video players. Thus, the data demonstrate that patients affected by severe pathological gambling show enhanced BDNF serum levels.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaAddiction Biology
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • BDNF
  • ELISA
  • SOGS
  • dopamine
  • pathological gambling
  • serum levels

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