Endothelial Dysfunction After High-Sugar Food Ingestion Is Improved By Endurance Exercise Performed On Previous Day

Ep Weiss, H Arif, Emanuele Marzetti, Dt Villareal, Jo Holloszy

Risultato della ricerca: Contributo in rivistaContributo a convegno


Endothelial function deteriorates after glucose ingestion. This may be attributed to hyperglycemia-induced oxidative stress. Acute endurance exercise might improve postprandial endothelial function by enhancing glucoregulation and reducing postprandial hyperglycemia. The objective was to determine whether endurance exercise performed 17 h before high-sugar-food ingestion attenuates postprandial impairment in endothelial function. Healthy men and women (n = 13; age: 48 +/- 17 y) were studied on 2 occasions: after > or = 48 h with no exercise and 17 h after a 60-min bout of endurance exercise. During each trial, brachial artery flow mediated dilation (FMD) was used to assess endothelial function before and after the ingestion of a candy bar and soft drink. Glucose, insulin, and thiobarbituric acid-reactive substances (TBARS), a marker of oxidative stress, were measured in blood obtained during each FMD measurement. The insulin sensitivity index was calculated from the glucose and insulin data. FMD decreased significantly after food ingestion in both trials. However, prior exercise shifted the entire FMD curve upward (main treatment effect: P = 0.0002), which resulted in a greater area under the curve for FMD (774 +/- 122%.min) than did no exercise (607 +/- 122%.min) (P = 0.01). Prior exercise shifted the glucose and insulin curves downward (main treatment effects: P = 0.05 and P = 0.0007, respectively) and resulted in a significantly greater insulin sensitivity index (10.8 +/- 0.7) than did no exercise (9.2 +/- 0.7) (P = 0.01). TBARS did not differ significantly between trials. Postprandial endothelial function was improved by endurance exercise performed approximately 17 h earlier. This effect was accompanied by exercise-induced improvements in insulin action and reductions in glycemia, but did not correspond with reductions in oxidative stress, as assessed by TBARS.
Lingua originaleEnglish
pagine (da-a)11-11
Numero di pagine1
RivistaMedicine and Science in Sports and Exercise
Stato di pubblicazionePubblicato - 2008
EventoAmerican College of Sports Medicine (ACSM) 55th Annual Meeting - Indianapolis, USA
Durata: 28 mag 200831 mag 2008


  • Diabetes
  • Oxidative stress


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