Endothelial cells, cholesterol, cytokines, and aging

Franco Pandolfi, S Tetè, D Tripodi, M Rosati, F Conti, G Maccauro, A Saggini, V Salini, E Cianchetti, A Caraffa, E Toniato, Ml Castellani, S Frydas, P Conti, Tc Theoharides

Risultato della ricerca: Contributo in rivistaArticolo in rivista

14 Citazioni (Scopus)

Abstract

It has been reported that high levels of cholesterol and triglycerides are associated with increased risk of developing atherosclerosis and shorter life. In fact, vascular endothelial dysfunction occurs during the human aging process. Accumulation of lipids in vascular endothelium activates leukocytes to produce cytokines and chemokines which recruit macrophages. On the other hand, macrophages augment inflammatory response and secrete vascular endothelial growth factor, a key cytokine that mediates angiogenesis and inflammatory response. In addition, hyperlipidaemia is one of the main risk factors for aging, hypertension and diabetes. Here, we review the interrelationship between endothelial cells, high level of cholesterol, and aging.
Lingua originaleEnglish
pagine (da-a)355-363
Numero di pagine9
RivistaInternational Journal of Immunopathology and Pharmacology
Stato di pubblicazionePubblicato - 2012

Keywords

  • atherosclerosis

Fingerprint Entra nei temi di ricerca di 'Endothelial cells, cholesterol, cytokines, and aging'. Insieme formano una fingerprint unica.

Cita questo